CANCER EPIDEMIOLOGY RESEARCH

癌症流行病学(CE)计划的长期目标是调查环境、生活方式 以及导致癌症发病率、发病率和死亡率增加的遗传因素，并将 生物标记物进入这些研究。为实现这一目标，将实现以下具体目标：1. Out分子流行病学研究，广泛包括从以下方面收集的数据的整合 具有流行病学数据的生物标本，以了解癌症风险。这些研究将利用 在近20个正在积极研究的队列中，许多人使用生物标本，并且在 使用生物标记物的CE计划。2.调查关键易感时间段的暴露情况如何变化 癌症易感性。将使用生命周期流行病学和事件发生的时间来捕捉风险因素 出生前和出生后的数据。3.在全球范围内进行流行病学研究。纵向 目前正在拉丁美洲、亚洲、东欧和西欧以及中东开展研究。 CE计划由来自公共学院3个系的15名成员(全部正式成员)组成 哥伦比亚大学内科和外科医学院的卫生和2个系。这个 该计划得到了几个大型联邦资助的合作赠款的支持，其中包括乳腺癌 家庭登记处，曼哈顿北部的NIEHS环境健康中心和一个超级基金基础 研究计划。 在赠款的最后一个预算年度(2006年7月1日至2007年6月30日)，CE计划成功地获得了 与癌症相关的赠款支持共计680万美元(直接费用)，其中包括国家癌症研究所的230万美元(直接费用) 资金，410万美元(直接成本)来自其他与癌症相关的同行审查资金，40万美元(直接成本)用于 与癌症相关的非同行审查资金。自上次提交以来的出版物总数 (即2003年至今)181个，其中42%是方案内的，36%是方案间的。

The long-term goals of the Cancer Epidemiology (CE) Program are to investigate environmental, lifestyle and genetic factors that lead to increased incidence, morbidity and mortality from cancer and to integrate biomarkers into these studies. To achieve this end, the following Specific Goals will be pursued: 1. Carry out molecular epidemiology studies that broadly include the integration of data collected from biospecimens with epidemiologic data to understand cancer risk. These studies will take advantage of almost 20 cohorts actively being studied, many with biospecimens, and the long history of research in the CE Program using biomarkers. 2. Investigate how exposures in key susceptible time periods alter cancer susceptibility. Lifecourse epidemiology and timing of events will be used to capture risk factor data from pre and postnatal periods. 3. Conduct epidemiologic studies around the globe. Longitudinal research is being carried out in Latin America, Asia, Eastern and Western Europe and the Middle East. The CE Program consists of 15 members (all full members) from 3 departments within the School of Public Health and 2 departments within the College of Physicians & Surgeons at Columbia University. The Program is supported by several large Federally-funded collaborative grants including the Breast Cancer Family Registry, the NIEHS Center for Environmental Health in Northern Manhattan and a Superfund Basic Research Program. For the last budget year of the grant (July 1, 2006 - June 30, 2007), the CE Program successfully obtained a total of $6.8M (direct costs) in cancer-relevant grant support, including $2.3M (direct costs) in NCI funding, $4.1 M (direct costs) in other cancer-related peer-reviewed funding, and $0.4M (direct costs) in cancer-related non-peer-reviewed funding. The total number of publications since the previous submission (i.e., 2003-present) was 181 of which 42% were intra-programmatic and 36% inter-programmatic.