CANCER EPIDEMIOLOGY RESEARCH

癌症流行病学（CE）计划的长期目标是调查环境、生活方式和疾病。 和遗传因素，导致癌症的发病率，发病率和死亡率增加， 生物标志物进入这些研究。为实现这一目标，将努力实现以下具体目标：1.携带 分子流行病学研究，广泛包括整合收集的数据， 生物样本与流行病学数据，以了解癌症风险。这些研究将利用 近20个正在积极研究的队列中，许多都有生物标本， CE计划使用生物标志物。2.调查关键易感时间段的暴露如何改变 癌症易感性将使用生命过程流行病学和事件时间来捕获风险因素 产前和产后的数据。3.在地球仪进行流行病学研究。纵向 目前正在拉丁美洲、亚洲、东欧和西欧以及中东进行研究。 CE计划由15名成员（全部为正式成员）组成，来自公共学院内的3个部门。 卫生部和哥伦比亚大学内科与外科学院的2个系。的 该计划得到了几个大型联邦资助的合作赠款的支持，包括乳腺癌 家庭登记处，北方曼哈顿的NIEHS环境健康中心和超级基金基本 研究计划。 在赠款的最后一个预算年度（2006年7月1日至2007年6月30日），CE计划成功地获得了 总计680万美元（直接成本）的癌症相关赠款支持，包括230万美元（直接成本）的NCI 其他癌症相关的同行评审资金为410万美元（直接成本）， 与癌症有关的非同行审查资金。自上次提交以来的出版物总数 (i.e., 2003年至今）为181项，其中42%为方案内，36%为方案间。

The long-term goals of the Cancer Epidemiology (CE) Program are to investigate environmental, lifestyle and genetic factors that lead to increased incidence, morbidity and mortality from cancer and to integrate biomarkers into these studies. To achieve this end, the following Specific Goals will be pursued: 1. Carry out molecular epidemiology studies that broadly include the integration of data collected from biospecimens with epidemiologic data to understand cancer risk. These studies will take advantage of almost 20 cohorts actively being studied, many with biospecimens, and the long history of research in the CE Program using biomarkers. 2. Investigate how exposures in key susceptible time periods alter cancer susceptibility. Lifecourse epidemiology and timing of events will be used to capture risk factor data from pre and postnatal periods. 3. Conduct epidemiologic studies around the globe. Longitudinal research is being carried out in Latin America, Asia, Eastern and Western Europe and the Middle East. The CE Program consists of 15 members (all full members) from 3 departments within the School of Public Health and 2 departments within the College of Physicians & Surgeons at Columbia University. The Program is supported by several large Federally-funded collaborative grants including the Breast Cancer Family Registry, the NIEHS Center for Environmental Health in Northern Manhattan and a Superfund Basic Research Program. For the last budget year of the grant (July 1, 2006 - June 30, 2007), the CE Program successfully obtained a total of $6.8M (direct costs) in cancer-relevant grant support, including $2.3M (direct costs) in NCI funding, $4.1 M (direct costs) in other cancer-related peer-reviewed funding, and $0.4M (direct costs) in cancer-related non-peer-reviewed funding. The total number of publications since the previous submission (i.e., 2003-present) was 181 of which 42% were intra-programmatic and 36% inter-programmatic.