CANCER GENETICS AND EPIGENETICS (CGE)

癌症遗传学和表观遗传学 (CGE)

• 批准号: 7669898
• 负责人: DEBRA J. WOLGEMUTH
• 金额: $ 1.61万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7669898
• 关键词: Address; Applications Grants; Area; Basic Cancer Research; Basic Science; Biological Assay; Budgets; Bystander Effect; Cancer Biology; Cancer Center Support Grant; Cell Cycle Progression; Cell Death; Cell Polarity; Cell division; Cell physiology; Cells; Chromatin; Chromosomal Instability; Clinical; Development; Developmental Biology; Diagnostic; Direct Costs; Environment; Epigenetic Process; Evaluation; Funding; Genetic Programming; Genome; Genome Stability; Genomic Instability; Genomics; Goals; Grant; Joints; Journals; Laboratories; Malignant - descriptor; Malignant Neoplasms; Modification; Molecular; Monitor; Numbers; Peer Review; Pilot Projects; Postdoctoral Fellow; Process; Productivity; Program Research Project Grants; Publications; Publishing; Radiation; Rate; Research; Research Personnel; Research Project Grants; Resource Sharing; Scientific Advances and Accomplishments; Scientist; Seminal; Students; Testing; Therapeutic; Therapeutic Effect; Toxic Environmental Substances; Training; Translating; Treatment Protocols; Universities; biodosimetry; cancer cell; cancer genetics; cell growth; cell motility; clinical application; high throughput screening; interest; member; nanofluidic; novel; pre-clinical; pre-doctoral; programs; repaired; response; small molecule; tumor initiation; tumorigenesis

The long-term goal of the Cancer Genetics and Epigenetics (CGE) Program is to pursue basic research on fundamental cellular processes relevant to cancer biology and to seek opportunities for translating the resulting information into clinical use. To this end, the following Specific Goals will be pursued: 1. Identify the molecular processes by which genomic instability is generated and contributes to oncogenesis; 2. Explore how epigenetic modifications of DMA and chromatin influence tumor initiation and progression; and 3. Elucidate the mechanisms underlying control of cell division and ascertain how these mechanisms are abrogated in cancer. The CGE Program is one of the two Basic Science Programs of the HICCC. In replacing the former Developmental Biology & Genetics Program it has been restructured to increase cancer relevance, and the heightened cancer focus of the new CGE Program is reflected by a 400% increase in NCI funding. The Program pursues its scientific goals by promoting interactions among CGE investigators and with other HICCC members, encouraging collaborative research projects and joint grant proposals, and providing a forum in which CGE investigators share their latest discoveries and consider the clinical value of their basic research findings. Potential clinical applications include identification and analysis of environmental toxins, modified therapeutic regimens to accommodate "radiation bystander" effects, development of biodosimetry, use of nanofluidic cassettes ("biochips") in diagnostic/predictive laboratory assays (including monitoring therapeutic responses), high-throughput screening to identify small molecules that modulate malignant processes, and pre-clinical testing of these molecules for therapeutic effects. The CGE Program consists of 32 members (all full members of the HICCC) from eleven departments at Columbia University. The Program is supported by several collaborative efforts, including a recently renewed, five-year $5.2M (direct costs) program project grant from the NCI entitled "Radiation Bystander Effects: Mechanisms" (P.I., Tom Hei). For the last budget year of the grant (July 1, 2006 - June.30, 2007), the CGE Program received a total of $17.12M (direct costs) in cancer-relevant grant support, including $3.69M (direct costs) in NCI funding, $12.95M (direct costs) in other cancer-related peer-reviewed funding, and $0.48M (direct costs) in cancer-related non-peer-reviewed funding. The total number of cancer-related publications by the current Program members since the previous submission (i.e., 2003-present) was 330, with 17.0% inter-programmatic and 12.4% intra-programmatic publications.

癌症遗传学和表观遗传学（CGE）计划的长期目标是进行基础研究， 与癌症生物学相关的基本细胞过程，并寻找机会将 将信息转化为临床应用。为此，将努力实现以下具体目标：1.识别 产生基因组不稳定性并促进肿瘤发生的分子过程; 2.探索 DNA和染色质的表观遗传修饰如何影响肿瘤的发生和发展; 3.阐明控制细胞分裂的潜在机制，并确定这些机制是如何 在癌症中消失。 CGE计划是CECC的两个基础科学计划之一。取代前者 发育生物学和遗传学计划，它已被重组，以增加癌症的相关性， 新的CGE计划对癌症的关注增加了400%，这反映在NCI资金的增加上。的 该计划通过促进CGE研究人员之间的互动以及与其他研究人员的互动来实现其科学目标。 鼓励合作研究项目和联合赠款提案，并提供 论坛，CGE研究人员分享他们的最新发现，并考虑其基本的临床价值， 研究结果。潜在的临床应用包括鉴定和分析环境毒素， 修改治疗方案以适应“辐射旁观者”效应，发展生物剂量学， 纳米流体盒（“生物芯片”）在诊断/预测实验室测定（包括监测）中的用途 治疗反应），高通量筛选以鉴定调节恶性肿瘤的小分子， 这些分子的治疗效果的临床前测试。 CGE计划由来自11个部门的32名成员组成（均为CECC的正式成员）， 哥伦比亚大学。该计划得到了几项合作努力的支持，包括最近的一项 美国国家癌症研究所（NCI）一项名为“辐射旁观者”的项目赠款，为期五年，金额为520万美元（直接成本） 效应：机制”（P.I.，Tom Hei）。对于赠款的最后一个预算年度（2006年7月1日至2007年6月30日）， CGE计划共收到了1712万美元（直接费用）的癌症相关赠款支持，包括 369万美元（直接成本）的NCI资金，1295万美元（直接成本）的其他癌症相关同行评审资金， 48万美元（直接费用）用于癌症相关的非同行评审资金。与癌症有关的 当前计划成员自上次提交以来的出版物（即，2003年至今）为330人， 其中17.0%为计划间出版物，12.4%为计划内出版物。