Graduate Training in Radiopharmaceutical Chemistry

描述(由申请人提供)： 放射性药物和放射性示踪化学的进步对卫生保健的实践产生了巨大的影响。然而，尽管国家研究委员会在1988年的一份报告中记录了这一多学科领域的博士化学家短缺的情况，但这种情况仍然存在。这种短缺使人们对开发机制产生了紧迫感，这些机制实现了在现代合成化学和放射化学方面提供扎实的研究生培训，同时为学生提供放射性制药和放射性示踪化学多学科领域的研究经验和接触的双重目标。这个T32在放射性制药和放射性示踪剂化学中的应用是一个多机构的研究生培养项目。该提案的总体计划是在化学原理方面建立坚实的基础，并附上一篇论文，这篇论文是由三个备受尊敬的机构(密苏里大学哥伦比亚分校、布鲁克海文国家实验室(BNL)和国家癌症研究所(NCI))对个人进行的研究得出的。为了实现我们所描述的目标，我们期望被选中的T32研究员比典型的研究生更有冒险精神和自我激励能力。这项提议的增值方法是，T32研究员不仅将在三个不同的地点学习基本技术，而且还将接受培训，认识目前生物医学科学面临的“大问题”，以及如何使用分子成像/治疗。他们将对这一领域有更全面的认识，这通常是在研究生、博士后和工作培训相结合的经历之后才会出现的。我们坚信，该项目固有的交叉受精将为T32研究员提供一种机制，在他们进行研究生培训之前体验他们即将进入的科学世界。因此，他们的博士后培训将更加专注，也更加富有成效。十名博士生将在最初的五年内入学。我们预计这些研究员将成功地(1)完全满足密歇根大学哥伦比亚分校的博士要求，(2)完成多学科研究，(3)在BNL或NCI经历了较长时间的实习，然后在第二个地点进行了较短的实习。该项目的毕业生将通过完成该项目成为该领域的未来参与者；然而，我们渴望他们成为该领域的未来领导者，教育我们的子孙后代。

DESCRIPTION (provided by applicant): Advances in radiopharmaceutical and radiotracer chemistry have made an enormous impact on the practice of health care. Yet, the shortage of PhD chemists in this multidisciplinary area persists even though it was documented in a National Research Council report in 1988. This shortage places a sense of urgency on developing mechanisms, which accomplish the dual goals of providing a solid graduate training in modern synthetic chemistry and radiochemistry while at the same time providing students with research experience and exposure in the multidisciplinary area of radiopharmaceutical and radiotracer chemistry. This T32 Application in Radiopharmaceutical and Radiotracer Chemistry is a multi-institutional graduate student training program. The overall plan of the proposal is to build a firm foundation in chemical principles, coupled with a dissertation that emanates from research conducted with individuals at three highly respected institutions (University of Missouri-Columbia (MU-Columbia), Brookhaven National Laboratory (BNL), and the National Cancer Institute (NCI)). We expect the selected T32 Fellows to be more adventurous and self- motivated than a typical graduate student in order to accomplish the objectives we describe. The value- added approach of this proposal is that the T32 Fellows will learn not only fundamental techniques at three different sites, but will also be trained in recognizing the "big questions" currently facing biomedical science and how molecular imaging/therapy can be used. They will gain a more comprehensive view of the field that generally only comes after the combined experiences of graduate, postdoctoral, and job training. We firmly believe that the cross-fertilization inherent in this program will provide the T32 Fellows a mechanism to experience the scientific world they are entering before they conduct postgraduate training. Their postdoctoral training will thereby be much more focused and much more productive. Ten PhD candidates will matriculate over an initial five year period. We expect the Fellows will have successfully (1) fullfilled the PhD requirements at MU-Columbia, (2) completed multidisciplinary research, and (3) experienced an extended internship at either BNL or the NCI followed by a shorter internship at the second site. Graduates of this program will be future participants in the field by completing this program; however, we aspire for them to become the future leaders in the field, teaching our future generations.