Graduate Training in Radiopharmaceutical Chemistry

描述（由申请人提供）： 放射性药物和放射性示踪剂化学的进步对医疗保健的实践产生了巨大的影响。然而，在这个多学科领域的博士化学家的短缺仍然存在，即使它是在1988年的国家研究理事会报告记录。这种短缺使人们迫切需要开发机制，以实现在现代合成化学和放射化学方面提供坚实的研究生培训的双重目标，同时为学生提供放射性药物和放射性示踪剂化学多学科领域的研究经验和曝光。这个T32在放射性药物和放射性示踪剂化学中的应用是一个多机构的研究生培训计划。该提案的总体计划是在化学原理方面建立坚实的基础，再加上一篇论文，该论文来自三个备受尊敬的机构（密苏里大学哥伦比亚分校（MU-哥伦比亚），布鲁克海文国家实验室（BNL）和国家癌症研究所（NCI））的个人研究。我们希望被选中的T32研究员比典型的研究生更有冒险精神和自我激励精神，以完成我们所描述的目标。这项提议的增值方法是，T32研究员不仅将在三个不同的地点学习基本技术，而且还将接受培训，认识到生物医学科学目前面临的“大问题”，以及如何使用分子成像/治疗。他们将获得该领域的更全面的看法，通常只有在研究生，博士后和工作培训的综合经验之后才能获得。我们坚信，该计划中固有的交叉施肥将为T32研究员提供一种机制，让他们在进行研究生培训之前体验他们正在进入的科学世界。因此，他们的博士后培训将更有针对性，更有成效。10名博士候选人将在最初的五年内入学。我们预计研究员将成功地（1）在MU-Columbia完成博士学位要求，（2）完成多学科研究，（3）在BNL或NCI经历了延长实习，然后在第二个地点进行较短的实习。该计划的毕业生将通过完成该计划成为该领域的未来参与者;然而，我们渴望他们成为该领域未来的领导者，教授我们的后代。

DESCRIPTION (provided by applicant): Advances in radiopharmaceutical and radiotracer chemistry have made an enormous impact on the practice of health care. Yet, the shortage of PhD chemists in this multidisciplinary area persists even though it was documented in a National Research Council report in 1988. This shortage places a sense of urgency on developing mechanisms, which accomplish the dual goals of providing a solid graduate training in modern synthetic chemistry and radiochemistry while at the same time providing students with research experience and exposure in the multidisciplinary area of radiopharmaceutical and radiotracer chemistry. This T32 Application in Radiopharmaceutical and Radiotracer Chemistry is a multi-institutional graduate student training program. The overall plan of the proposal is to build a firm foundation in chemical principles, coupled with a dissertation that emanates from research conducted with individuals at three highly respected institutions (University of Missouri-Columbia (MU-Columbia), Brookhaven National Laboratory (BNL), and the National Cancer Institute (NCI)). We expect the selected T32 Fellows to be more adventurous and self- motivated than a typical graduate student in order to accomplish the objectives we describe. The value- added approach of this proposal is that the T32 Fellows will learn not only fundamental techniques at three different sites, but will also be trained in recognizing the "big questions" currently facing biomedical science and how molecular imaging/therapy can be used. They will gain a more comprehensive view of the field that generally only comes after the combined experiences of graduate, postdoctoral, and job training. We firmly believe that the cross-fertilization inherent in this program will provide the T32 Fellows a mechanism to experience the scientific world they are entering before they conduct postgraduate training. Their postdoctoral training will thereby be much more focused and much more productive. Ten PhD candidates will matriculate over an initial five year period. We expect the Fellows will have successfully (1) fullfilled the PhD requirements at MU-Columbia, (2) completed multidisciplinary research, and (3) experienced an extended internship at either BNL or the NCI followed by a shorter internship at the second site. Graduates of this program will be future participants in the field by completing this program; however, we aspire for them to become the future leaders in the field, teaching our future generations.