Drugs, sexual impulsivity, HIV: Psychosocial and cognitive risk factors of YMSM

毒品、性冲动、艾滋病毒：YMSM 的心理社会和认知危险因素

• 批准号: 7685401
• 负责人: Dorian E Traube
• 金额: $ 16.85万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7685401
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adult; Age; Alcohol or Other Drugs use; Anti-HIV Agents; Anus; Area; Award; Behavior; Behavioral; Behavioral Model; Case Study; Classification; Cognitive; Coitus; Communities; Complex; Data; Data Analyses; Development; Drug abuse; Drug usage; Environmental Risk Factor; Evaluation; Funding; Goals; Guide prevention; HIV; HIV Infections; Health; Health Promotion; Health behavior; Heterosexuals; High Prevalence; Impulsivity; Individual; Intervention; Lead; Life; Longitudinal Studies; Male Adolescents; Methamphetamine; Modeling; Multivariate Analysis; NIH Program Announcements; National Institute of Drug Abuse; Pharmaceutical Preparations; Population; Prevalence; Preventive Intervention; Reporting; Research; Research Personnel; Risk; Risk Behaviors; Risk Factors; Risk Reduction; Risk-Taking; Science; Sexual Partners; Sexually Transmitted Diseases; Shapes; Testing; Theoretical model; Youth; base; career; cohort; coping; design; health belief; health disparity; men; men who have sex with men; metropolitan; peer; psychologic; psychosocial; public health relevance; response; sex risk; social; social cognitive theory; theories; therapy development; transmission process

DESCRIPTION (provided by applicant): Unprotected sexual intercourse between men constitutes 58% of all reported cases of AIDS and 80% of HIV cases 1,2. Rates of HIV infection among 15 to 24 year olds continue to increase with MSM behavior remaining the leading cause of HIV infection among adolescent males 1,2. Over 90% of YMSM have reported having more than one sexual partner in the past 6 months and between 33% and 49% have had unprotected anal intercourse during the same time3. Studies show that use of stimulants, particularly methamphetamine, may influence risky sexual practices and contribute to the most recent wave of HIV and other sexually transmitted infections (STIs)4-6. Systematic development of theory has been identified as a crucial step in efficacious intervention development, but previous conceptual models have focused on a relatively limited array of explanatory constructs. However, Social Action Theory (SAT)7 provides a promising model for examining the risk behavior of YMSM, because it includes individual as well as social and contextual determinants. SAT remains to be tested for use in the field of HIV and with YMSM, because this model was originally conceived as a general health promotion model for the adult population. Using data from the Dr. Kipke's NIDA funded "Healthy Young Men Study" (HYM), this study will conduct multivariate analysis to test this model for use with the YMSM population. The specific aims of this study are to: 1) To empirically validate the chain of relationships depicted in Social Action Theory to determine if the theory addresses the interaction of individual, contextual, and social correlates of sexual and drug risk taking behaviors as they relate to YMSM; and 2) To further validate SAT by testing and incorporating competing theoretical relationships depicted in other behavioral theory models to develop a comprehensive theory of the social, psychosocial and cognitive risk factors for drug use, sexual impulsivity, and HIV among YMSM to guide prevention intervention efforts. . This study will contribute to the objectives of the AIDS-Science Track Award for Research Transition by 1) supporting a New Researcher; 2) addressing the NIDA research objective in the area of HIV, drug abuse, impulsivity, and coping strategies of an at-risk, under represented population; and 3) through refinement of a comprehensive theoretical model, we will provide a platform for developing interventions that address risk behavior related to HIV transmission among YMSM. PUBLIC HEALTH RELEVANCE: This study will contribute to effective HIV interventions for at-risk youth by developing a model to understand how environmental risk factors, impulsivity, and coping strategies converge into drug abuse and sexual risk taking.

描述（由申请人提供）：男性之间无保护的性交占所有报告的艾滋病病例的 58%，占艾滋病毒病例的 80%1,2。 15 至 24 岁人群的 HIV 感染率持续上升，MSM 行为仍然是青春期男性 HIV 感染的主要原因 1,2。超过 90% 的 YMSM 报告在过去 6 个月内有超过一名性伴侣，并且 33% 至 49% 的人在同一时间段内有过无保护的肛交3。研究表明，使用兴奋剂，特别是甲基苯丙胺，可能会影响危险的性行为，并导致最近一波艾滋病毒和其他性传播感染 (STI)4-6。理论的系统发展已被认为是有效干预发展的关键步骤，但以前的概念模型侧重于相对有限的解释性结构。然而，社会行动理论 (SAT)7 为检验 YMSM 的风险行为提供了一个有前途的模型，因为它包括个人以及社会和背景决定因素。 SAT 在 HIV 领域和 YMSM 中的使用仍有待测试，因为该模型最初被设想为成年人口的一般健康促进模型。这项研究将利用 Kipke 博士的 NIDA 资助的“健康年轻人研究”(HYM) 的数据进行多变量分析，以测试该模型是否适用于 YMSM 人群。本研究的具体目的是： 1) 实证验证社会行动理论中描述的关系链，以确定该理论是否解决了与 YMSM 相关的性行为和毒品冒险行为的个人、背景和社会相关因素之间的相互作用； 2) 通过测试和纳入其他行为理论模型中描述的竞争理论关系来进一步验证 SAT，以开发 YMSM 中吸毒、性冲动和 HIV 的社会、心理社会和认知风险因素的综合理论，以指导预防干预工作。 。这项研究将通过以下方式为艾滋病科学研究转型奖的目标做出贡献：1）支持新研究人员； 2) 解决 NIDA 在艾滋病毒、药物滥用、冲动和高危、代表性不足人群的应对策略领域的研究目标； 3) 通过完善综合理论模型，我们将提供一个平台来制定干预措施，解决 YMSM 中与艾滋病毒传播相关的风险行为。公共卫生相关性：这项研究将通过开发一个模型来了解环境风险因素、冲动和应对策略如何融合到药物滥用和性冒险行为中，从而有助于对高危青少年进行有效的艾滋病毒干预。