Error-Related Brain Activity and Risk for Anxiety and Depressive Disorders

描述（由申请人提供）：错误相关负波（ERN）是在头皮处观察到的一种皮层电反应，在错误反应后约50 ms达到最大值。许多研究报告了焦虑和抑郁参与者的ERN增加，最近，在成功治疗之前和之后的焦虑儿科患者中报告了类似的结果模式。其他研究也报告说，在那些报告了高水平的负面情绪和惩罚敏感性人格特质的受试者中，与错误相关的大脑活动增加，这些人格特质在焦虑症和抑郁症中都有所升高。总的来说，这些结果表明，ERN增加可能反映了自我监测过程中的信息处理异常，反映了焦虑和抑郁障碍的共同风险因素。为了解决这种可能性，本研究将检查ERN与两个众所周知的风险因素有关的发展焦虑和抑郁症：家族性精神病理学和气质措施的负面情绪和行为抑制。本研究的总体目标是评估错误相关的大脑活动与焦虑和抑郁的发展之间的关系，并评估错误相关的大脑活动作为情感性精神病理学的潜在内表型的效用。此外，本研究将有助于文献的发展神经生物学的个性和气质的个体差异。公共卫生相关性：本研究以300名6奥尔兹为样本，探讨了与错误相关的大脑活动与父母精神病理学和行为抑制和消极情绪实验室测量之间的关系。本研究的目的是检验错误相关脑活动的变化是否与这些众所周知的发展焦虑和抑郁障碍的危险因素有关。

DESCRIPTION (provided by applicant): The error-related negativity (ERN) is an electrocortical response observed at the scalp that is maximal approximately 50 ms after an erroneous response. A number of studies have reported increased ERNs in anxious and depressed participants, and recently, a similar pattern of results has been reported in anxious pediatric patients both before and after successful therapy. Other studies have reported increased error- related brain activity in subjects who report high levels of negative emotionality and punishment sensitivity personality traits that are elevated across both anxiety disorders and depression. Collectively, these results suggest that an increased ERN may reflect information-processing abnormalities during self-monitoring that reflect a shared risk factor for anxiety and depressive disorders. To address this possibility, the present study will examine the ERN in relation to two well-known risk factors related to the development of anxiety and depressive disorders: familial psychopathology and temperamental measures of negative emotionality and behavioral inhibition. The overall goal of this study is to evaluate the relationship between error-related brain activity and the development of anxiety and depression, and to assess the utility of error-related brain activity as a potential endophenotype for affective psychopathologies. Additionally, the present study will contribute to the literature on the developmental neurobiology of individual differences in temperament and personality. PUBLIC HEALTH RELEVANCE: This study explores the relationship between error-related brain activity, and parental psychopathology and laboratory measures of behavioral inhibition and negative emotionality in a sample of 300 6-year olds. The present study aims to examine whether variation in error- related brain activity relates to these well-known risk factors for developing both anxiety and depressive disorders.