The error-related negativity (ERN) and psychopathology: toward an endophenotype.
The error-related negativity (ERN) and psychopathology: toward an endophenotype.
复制标题
DOI：
10.1016/j.cpr.2008.07.003
复制
发表时间：
2008-12
影响因子：
12.8
通讯作者：
Hajcak, Greg
中科院分区：
文献类型：
--
作者：
Olvet, Doreen M.;Hajcak, Greg
ERN是事件相关电位的负向偏转，在错误发生后约50 ms达到峰值。ERN被认为反映了前扣带皮层（ACC）的早期错误处理活动。首先，我们回顾目前的功能，神经生物学和发展的数据ERN。接下来，ERN被讨论的三个精神疾病的异常反应监测的特点：焦虑症，抑郁症和药物滥用。这些数据表明，增加和减少错误相关的大脑活动与内在和外在的精神病理学的维度，分别。最近的数据进一步表明，异常错误处理索引的ERN指数特质，但不是状态相关的症状，特别是与焦虑。总体而言，这些数据点ERN在研究精神疾病风险的效用，并讨论了内在表型结构。
The ERN is a negative deflection in the event-related potential that peaks approximately 50 ms after the commission of an error. The ERN is thought to reflect early error-processing activity of the anterior cingulate cortex (ACC). First, we review current functional, neurobiological, and developmental data on the ERN. Next, the ERN is discussed in terms of three psychiatric disorders characterized by abnormal response monitoring: anxiety disorders, depression, and substance abuse. These data indicate that increased and decreased error-related brain activity is associated with the internalizing and externalizing dimensions of psychopathology, respectively. Recent data further suggest that abnormal error-processing indexed by the ERN indexes trait- but not state-related symptoms, especially related to anxiety. Overall, these data point to utility of ERN in studying risk for psychiatric disorders, and are discussed in terms of the endophenotype construct.
登录
查看更多内容
影响因子：
4.8
作者：
Bates, AT;Liddle, PF;Ngan, ETC
通讯作者：
Ngan, ETC
影响因子：
2.9
作者：
de Bruijn, Ellen R. A.;Sabbe, Bernard G. C.;Verkes, Robbert J.
通讯作者：
Verkes, Robbert J.
影响因子：
3.7
作者：
Anokhin, Andrey P.;Golosheykin, Simon;Heath, Andrew C.
通讯作者：
Heath, Andrew C.
影响因子：
4.6
作者：
Brown, TA;Chorpita, BF;Barlow, DH
通讯作者：
Barlow, DH
影响因子：
25
作者：
Amodio, David M.;Jost, John T.;Yee, Cindy M.
通讯作者：
Yee, Cindy M.