Transfusion Medicine/Hemostasis Clinical Research Network
输血医学/止血临床研究网络
基本信息
- 批准号:7681055
- 负责人:
- 金额:$ 18.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-09-30 至 2012-08-31
- 项目状态:已结题
- 来源:
- 关键词:AdultAnemiaAreaBloodChildClinicalClinical ResearchClinical TrialsClinical Trials NetworkCollaborationsData AnalysesDiseaseFutureGoalsHematologyHemophilia AHemostatic AgentsHemostatic functionInstitutionInvestigational DrugsKnowledgeMedicineNeutropeniaPatientsProtocols documentationResearchResourcesReview CommitteeRoleTherapy Clinical TrialsThrombocytopeniaTransfusionblood productcombatcytokine therapyformycin triphosphategranulocytenovelresearch study
项目摘要
DESCRIPTION (provided by applicant)
This application responds to RFA-HL-06-108 entitled "Announcement of a Limited Competition for the Continuation of the Transfusion Medicine/Hemostasis Clinical Trials Network" (TMH CTH) (U01). Clinical issues in transfusion medicine and hemostasis often deal with a large number of relatively uncommon diseases. It has been difficult to answer clinical questions about specific areas of transfusion medicine/hemostasis due to the lack of a critical number of patients at any given institution. The TMH Network was established in 2002, composed of 17 core centers recognized as being leaders in this field of medicine. It is a national resource assigned with the purpose of advancing knowledge and understanding in the area of transfusion medicine and hemostasis. The Network has promoted the comparison of novel management strategies of potential benefit for children and adults with hemostatic disorders and has evaluated novel as well as existing blood therapies and cytokines for the treatment of hematologic disorders. The emphasis over the last 4 years has been on identifying areas of transfusion medicine/hemostasis that need to be scientifically explored, developing research protocols with a goal toward facilitating optimal therapy, initiating clinical trials, and moving towards completion and data analysis. Therapeutic trials have involved the use of investigational drugs or blood products, including those already approved and used, as well as those not currently used. The Network emphasizes the strength of the close collaboration between experts in transfusion medicine and hematology to potentially explore the role for other blood derived products, such as granulocytes. Three research studies have been approved by the Protocol Review Committee and DSMB (PLADO, SHIP and RICH) and are currently being conducted at participating centers or are on the verge of initiating clinical trials. The Network has a pipeline of several other studies that are close to being activated (HIT, Granulocyte Study, CVAD, STAR). Each year, thousands of patients receive treatment for diseases like "FTP and Hemophilia. Many millions more have problems with thrombocytopenia, neutropenia and anemia. This network has established a building block for future research to help treat and combat these problems.
描述(由申请人提供)
本申请响应RFA-HL-06-108号文件,标题为“继续开展输血药物/止血临床试验网络的有限竞争公告”(TMH Cth)(U01)。在输血医学和止血方面的临床问题往往涉及大量相对罕见的疾病。由于任何特定机构缺乏关键数量的患者,因此很难回答有关输血药物/止血的具体领域的临床问题。TMH网络成立于2002年,由17个被公认为这一医学领域的领导者的核心中心组成。它是一项国家资源,目的是增进输血医学和止血领域的知识和了解。该网络促进了对患有止血疾病的儿童和成人的潜在益处的新管理战略的比较,并评估了用于治疗血液病的新的和现有的血液疗法和细胞因子。过去4年的重点一直是确定需要科学探索的输血药物/止血领域,开发研究方案,以促进最佳治疗,启动临床试验,并走向完成和数据分析。治疗试验涉及使用研究药物或血液产品,包括那些已经批准和使用的药物,以及那些目前没有使用的药物或血液产品。该网络强调输血医学和血液学专家之间密切合作的力量,以潜在地探索其他血液衍生产品的作用,如粒细胞。三项研究已获得议定书审查委员会和药物监测系统(PLADO、SHIP和RICH)的批准,目前正在参与中心进行或即将启动临床试验。该网络还有其他几项即将启动的研究(HIT、粒细胞研究、CVAD、STAR)。每年,数以千计的患者接受FTP症和血友病等疾病的治疗。还有数百万人患有血小板减少症、中性粒细胞减少症和贫血。这个网络为未来帮助治疗和对抗这些问题的研究奠定了基础。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('RONALD G STRAUSS', 18)}}的其他基金
PROPHYLACTIC PLATELET DOSE STRATEGY TO PREVENT BLEEDING IN THROMBOCYTOPENIA
预防血小板减少症出血的预防性血小板剂量策略
- 批准号:
7604833 - 财政年份:2007
- 资助金额:
$ 18.75万 - 项目类别:
PROPHYLACTIC PLATELET DOSE STRATEGY TO PREVENT BLEEDING IN THROMBOCYTOPENIA
预防血小板减少症出血的预防性血小板剂量策略
- 批准号:
7377042 - 财政年份:2006
- 资助金额:
$ 18.75万 - 项目类别:
CLINICAL AND IMMUNO-HEMATOLOGIC EFFECTS OF PLACENTAL BLOOD
胎盘血的临床和免疫血液学影响
- 批准号:
7201398 - 财政年份:2005
- 资助金额:
$ 18.75万 - 项目类别:
PROPHYLACTIC PLATELET DOSE STRATEGY TO PREVENT BLEEDING IN THROMBOCYTOPENIA
预防血小板减少症出血的预防性血小板剂量策略
- 批准号:
7201375 - 财政年份:2005
- 资助金额:
$ 18.75万 - 项目类别:
Clinical and Immuno-Hematologic Effects of Placental Blood
胎盘血的临床和免疫血液学影响
- 批准号:
7040844 - 财政年份:2004
- 资助金额:
$ 18.75万 - 项目类别:
Transfusion Medicine/Hemostasis Core Clinical Center
输血医学/止血核心临床中心
- 批准号:
6569420 - 财政年份:2002
- 资助金额:
$ 18.75万 - 项目类别:
Transfusion Medicine/Hemostasis Core Clinical Center
输血医学/止血核心临床中心
- 批准号:
7122531 - 财政年份:2002
- 资助金额:
$ 18.75万 - 项目类别:
Transfusion Medicine/Hemostasis Core Clinical Center
输血医学/止血核心临床中心
- 批准号:
6782716 - 财政年份:2002
- 资助金额:
$ 18.75万 - 项目类别:
Transfusion Medicine/Hemostasis Core Clinical Center
输血医学/止血核心临床中心
- 批准号:
6662632 - 财政年份:2002
- 资助金额:
$ 18.75万 - 项目类别:
Transfusion Medicine/Hemostasis Clinical Research Network
输血医学/止血临床研究网络
- 批准号:
7277971 - 财政年份:2002
- 资助金额:
$ 18.75万 - 项目类别:
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