New Orleans Adolescent Medicine Trials Unit

新奥尔良青少年医学试验单位(ATU)是一个建议的(也是目前的)合作临床 青少年医学艾滋病毒/艾滋病干预试验网络(ATN)的活动网站，一个全国性的 研究努力。ATN的主要任务是进行研究，包括独立研究和 与其他现有研究网络和研究人员合作，在学龄前、青少年和 感染艾滋病毒或有感染艾滋病毒风险的年轻人。这项研究的公共卫生目标 努力支持限制艾滋病毒在年轻人中的影响和传播， 二级预防、三级预防。研究结果将有助于让个人和社区了解 对受艾滋病毒影响最严重的年轻人可接受和有效的艾滋病毒预防战略。 新奥尔良ATU计划通过继续发展继续进行初级预防研究 连接到保护：新奥尔良(C2P)。C2P：新奥尔良正在开发一种基于社区的 支持评估行为、疫苗和其他生物医学模式的临床试验的基础设施 对于新奥尔良最有可能感染和传播艾滋病毒的青年，特别是非裔美国青年 女人。计划包括对这一过程的评估，对此中有效行为程序的翻译 社区，教育社区有关临床试验、可接受性、使用和效果的方法 疫苗和杀微生物剂等生物医学进展。 计划进行二级预防研究，以保护感染艾滋病毒的青年的健康和功能。 研究包括：管理策略，如短周期抗逆转录病毒疗法和评估乙肝病毒 免疫接种时间表；关键领域的调查，如生长期间治疗的长期影响 而成熟、青少年特有的HIV发病机制，以及疫苗影响下的免疫恢复 和以免疫为基础的疗法；应对艾滋病毒引起的恶性肿瘤等共病的战略；以及 促进坚持药物治疗和防止艾滋病毒传播给他人的战略。 三级预防研究的目的是改善对病情严重的青少年的临床管理。 或者几乎没有剩余的治疗选择。每一项研究都需要自己独特的方法，所有的研究都将 需要跨学科合作，以解决艾滋病毒感染者和高危人群的复杂性。

The New Orleans Adolescent Medicine Trials Unit (ATU) is a proposed (and current) collaborating clinical site for.the activites of the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN), a national research effort. The primary mission of the ATN is to conduct research, both independently and in collaboration with other existing research networks and investigators, in pre-adolescents, adolescents and young adults who are HIV infected or are at risk for HIV infection. The public health goal of this research effort is to support limitation of the impact and spread of HIV among young people through primary, secondary, and tertiary prevention. Research results will serve to inform individuals and communities about HIV prevention strategies that are acceptable and effective for young people most affected by HIV. The New Orleans ATU plans to continue primary prevention research through the continued development of Connect to Protect: New Orleans (C2P). C2P: New Orleans is developing a community-based infrastructure to support clinical trials evaluating behavioral, vaccine and other biomedical modalities tailored for New Orleans youth most at risk for HIV infection and transmission, particularly African-American young women. Plans include evaluation of this process, of translation of effective behavioral programs in this community, of ways of educating the community about clinical trials, of acceptability, use and effect of biomedical advances such as vaccines and microbicides. Secondary prevention studies are planned to preserve the health and functioning of HIV-infected youth. Studies include: management strategies such as short-cycle ARV therapy and evaluation of HBV immunization schedules; investigations of key areas such as long-term effects of therapies during growth and maturation, adolescent-specific HIV pathogenesis, and immune recovery under the influence of vaccine and immune-based therapies; strategies to address co-morbidities such as HIV-induced malignancies; and strategies to promote adherence to medical therapies and prevention of HIV transmission to others. Tertiary prevention studies are aimed at improving the clinical management of youth who present very ill or have few remaining therapeutic options. Each study will require its own unique methods, and all will require interdisciplinary collaborations to address the complexity of HIV infected and at-risk populations.