Small Animal Imaging

小动物癌症成像研究机构(SACIRF)为癌症研究人员提供了最新的 小动物实验活体成像的技术和技巧。该设施包括最新的-- ART仪器，包括磁共振方式(MR，Bruker4.7 T，40 cm Biospec)， X射线计算机断层扫描(增强型视觉系统的微型CT和正在开发的体积CT 与通用电气合作)、投影射线照相术(Faxitron)和核成像(M.Cam Gamma 西门子公司的摄像头和协和微系统公司的微型PET)。在此期间将添加光学成像 获奖第一年(仪器将与生物医学工程公司合作开发，位于 德克萨斯大学奥斯汀分校)。这一工具代表着MDACC的300万美元投资。这个 SACIRF已在动物支持设施中为这些仪器分配了空间，以便利纳入 正在进行的癌症研究中的成像研究，以及专门的办公室和开发实验室空间，以 支持工厂运营。教职员工在每个医疗设备领域都有很好的资质，包括 目前的图像采集和图像分析技术。专业领域包括定量组织 表征(MR)、微血管生理学成像(MR、核、CT和光学)、扩散成像 用于估计细胞密度(MR)、代谢成像(核、正电子发射断层扫描[PET]、光学 以及血管成像(MR、CT和X光)。该设施的服务包括 成像协议设计、定制定位系统、定制数据采集硬件和软件、图像 分析、数据存档、提供硬拷贝和数字数据交付以及数据库维护。这个 兽医核心包括一个专门的支持团队，提供高效的成像研究和非常 成像过程中动物死亡率低。兽医中心提供的服务 包括制定针对每个实验设计兽医支持方案，以及咨询 关于将成像程序纳入现有协议以获得机构动物护理和使用 委员会批准。到目前为止，代表13个项目的75名调查人员使用了设施仪器。 42%的用户是同行评议资助的调查人员。使用率继续增加，因为设施和其 能力变得更为当地癌症研究界所知。该设施的能力 继续增长以满足实验需求。出版物正在快速发展，尽管 只出版了几本，接受率已经接近100%。为SACIRF提供的资金目前正在 CCSG(43%)、用户费用(36%)和MDACC(21%)。

The Small Animal Cancer Imaging Research Facility (SACIRF) provides cancer investigators with the latest technology and techniques for experimental in vivo imaging of small animals. The facility includes state-ofthe- art instrumentation, including the modalities of magnetic resonance (MR, Bruker4.7 T, 40 cm Biospec), x-ray computed tomography (micro-CT from Enhanced Vision Systems and volume CT being developed in collaboration with General Electric), projection radiography (Faxitron), and nuclear imaging (M.Cam gamma camera from Siemens and micro-PET from Concorde Microsystems). Optical imaging will be added during the first year of the award (instrumentation to be developed in collaboration with Biomedical Engineering at The University of Texas-Austin). This instrumentation represents a >$3M investment by MDACC. The SACIRF has allocated space for the instruments in the animal support facilities to facilitate the inclusion of the imaging studies in ongoing cancer research, and dedicated office and developmental laboratory space to support the facility operation. The faculty and staff are well-qualified in each of the modality areas, including current image acquisition and image analysis techniques. Specialty areas include quantitative tissue characterization (MR), imaging of microvascular physiology (MR, nuclear, CT and optical), diffusion imaging for estimating cellular density (MR), metabolic imaging (nuclear, positron emission tomography [PET], optical and MR spectroscopy), and vascular imaging (MR, CT, and x-ray). The services of the facility include imaging protocol design, custom positioning systems, custom data acquisition hardware and software, image analysis, data archiving, provision of hardcopy and digital data delivery, and database maintenance. The Veterinary Core includes a dedicated support team that provides highly efficient imaging studies and a very low mortality rate of animals during the imaging procedures. Services provided from the Veterinary Core include development of veterinary support protocols specific to each experimental design, and consultation on the inclusion of imaging procedures into existing protocols to obtain Institutional Animal Care and Use Committee approval. To date, 75 investigators representing 13 programs have used facility instrumentation. 42% of the users are peer-review-funded investigators. Utilization continues to increase as the facility and its capabilities become better known to the local cancer research community. The capabilities of the facility continue to grow to meet experimental demands. Publications are evolving at a rapid pace, and although only a few are published, the acceptance rate has been nearly 100%. Funding for the SACIRF is currently CCSG (43%), user fees (36%), and MDACC (21%).