Advanced micro-PET/CT/RT System for Translational Radiation Oncology Applications

用于转化放射肿瘤学应用的先进微型 PET/CT/RT 系统

• 批准号: 8962231
• 负责人: JOHN D. HAZLE
• 金额: $ 36万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2015-12-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8962231
• 关键词: 3-Dimensional; Adopted; Anatomy; Animal Disease Models; Animals; Beds; Biological; Biological Process; Caliber; Clinical; Clinical Research; Computer software; Databases; Dose; Effectiveness; Electronics; Evaluation; Functional Imaging; Geometry; Goals; Human; Image; Imaging technology; Knowledge; Lead; Length; Logistics; Lung Neoplasms; Measures; Methods; Modeling; PET/CT scan; Performance; Phase; Photons; Play; Positioning Attribute; Positron-Emission Tomography; Problem Solving; Procedures; Protocols documentation; Radiation; Radiation Oncologist; Radiation Oncology; Radiation therapy; Radioisotopes; Research; Research Methodology; Research Personnel; Resolution; Risk; Roentgen Rays; Role; Scientist; Semiconductors; Solutions; Source; System; Technology; Testing; Therapeutic Studies; Translating; Translational Research; Tumor Volume; Uncertainty; Variant; X-Ray Computed Tomography; base; cancer therapy; chemoradiation; clinical application; clinically relevant; data acquisition; design; detector; follow-up; image guided; image guided radiation therapy; image registration; imaging modality; imaging system; improved; in vivo; innovation; microCT; molecular imaging; new technology; novel; prevent; prototype; public health relevance; quantitative imaging; radiation effect; radiation response; research study; response; sensor; success; theories; thyroid neoplasm; treatment planning; tumor

 DESCRIPTION (provided by applicant): For radiation therapy (RT), the capability to precisely define and delivery radiations with the targeted distribution and dose level and to adapt the treatment plan based on the tumor biological response to RT is the key for any successful clinical therapy and translational research. For improving the current RT protocols and develop new novel RT strategies, it is critical to conduct translational RT researches with the technologies and procedures analogous to those applied in clinical RT practice so that the research methods and results are clinically relevant and can be effectively translated to clinical studies and applications. The goal of this project is to establish practical and advanced PET/CT image-guided radiation therapy (IGRT) capability for translational RT researches. The significance and impact of this project are very clear: it will overcome a critical technical obstale to transform the current practice of RT research that is almost solely relied on anatomic CT images to the one guided by functional images with the knowledge of actual tumor biological status and function. The success of this project is expected to have lasting impact to improving and accelerating the translational RT research and profound benefits to enhancing the cancer treatment. The research aims to develop an advanced animal PET and integrate it with an existing micro-CT/RT, evaluate and improve the performance through experiments of phantom imaging and system modeling, and conduct pilot animal studies to test the capability PET/CT image-guided translational radiation oncology applications. The newly developed PET detector technologies will be applied to overcome technical challenges to achieve high sensitivity (23%) and high, uniform resolution (1 mm) required by the quantitative imaging of small size tumor for RT studies. The novel imaging technology to be developed by this project should also be practical so that it can be adopted for other micro-CT/RT systems without fundamental technical difficulties.

 描述(申请人提供)：对于放射治疗(RT)，能够准确地定义和提供具有目标分布和剂量水平的辐射，并根据肿瘤对RT的生物学反应调整治疗计划的能力是任何成功的临床治疗和转化性研究的关键。为了改进现有的RT方案，开发新的RT策略，利用与临床RT实践类似的技术和程序进行翻译RT研究，使研究方法和结果具有临床意义，并有效地转化为临床研究和应用是至关重要的。该项目的目标是建立实用和先进的PET/CT图像引导放射治疗(IGRT)能力，用于转化型RT研究。这个项目的意义和影响是非常明确的：它将克服一个关键的技术障碍，将目前几乎完全依赖解剖CT图像的RT研究实践转变为由功能图像引导的、具有实际肿瘤生物学状态和功能的实践。该项目的成功有望对改进和加快翻译RT研究产生持久的影响，并将对提高癌症的治疗水平产生深远的影响。本研究旨在开发一种先进的动物PET并将其与现有的Micro-CT/RT相集成，通过体模成像和系统建模实验来评估和改进其性能，并进行动物实验以测试PET/CT图像引导的平移放射肿瘤学应用的能力。新开发的PET探测器技术将被用于克服技术挑战，以实现用于RT研究的小尺寸肿瘤的定量成像所需的高灵敏度(23%)和高、均匀分辨率(1 Mm)。本项目将开发的新型成像技术也应具有实用性，以便在没有根本技术困难的情况下适用于其他微型CT/RT系统。