Tissue Procurement and Banking Facility

组织采购和库存设施（TPBF）为所有基础科学和临床研究人员提供 MDACC可接触通过治疗性切除或活检切除的人体组织。的 共享资源的目标是：1）保持灵活的专门组织获取资源， 为提出请求的研究者提供有效和迅速的交付， 来自手术患者的良好表征和定制处理的肿瘤和对照组织 2）维持和改善全机构的集中组织， 采购和银行核心设施，根据NCI最佳实践提供样本， 生物样本资源，并与当前、新兴和预期的分析方法兼容 3）与其他机构数据库的接口，以加强基于内联网的 数据库，以便提供流行病学，家族史，患者治疗和患者结果; 4）支持 个人有计划地管理和资助卫星组织库， 机构，包括由疾病站点、SPORE和P01维护的机构;以及5）满足联邦、州 研究和保护人体组织的机构监管要求 科目该设施占地379平方英尺和187平方英尺的两个外科病理学套房，并有一个 独立的2,500平方英尺的安全、监控、环境控制设施，配有21个冰柜。额外组织 TPBF使用的处理室位于每个设有手术室的诊所。TPBF配备了一名 主任，实验室经理，2名组织采购专家，2名组织实验室助理，a 协调员和临床研究协调员。在上一个资助期间，154，122个标本 共收集了21,902个病例。共分发了124，378份标本，其中87%提供给了14 同行评审资助的卫星银行，5%给同行评审资助的个人研究者，7%给非同行 审查资助的个人研究者，1%的非同行审查资助的卫星银行。个人 研究人员可以从卫星库和TPBF获得组织标本。使用TPBF服务的有： 来自21个CCSG项目中19个项目的66名研究者。65%的个人用户获得了同行评审的资金 占个人用户使用量的40%。未来计划的重点是与 临床、流行病学、肿瘤登记和方案数据库，以通过 TissueStation和ResearchStation软件计划;质量控制/质量保证，包括评价 使用美国国家癌症研究所的生物样本库评估工具（BRET）;完成 符合2007年6月发布的NCI生物样本资源最佳实践， 1988年临床实验室改进法案，并继续扩大能力，以满足研究需求。

The Tissue Procurement and Banking Facility (TPBF) provides all basic science and clinical investigators at MDACC with access to human tissues that have been removed by therapeutic resection or biopsy. The goals of the shared resource are to: 1) maintain a flexible specialized tissue-procurement resource that provides requesting investigators efficient and expeditious delivery to requesting investigators of freshlyobtained well-characterized and custom-processed tumor and control tissue from patients in operating rooms, procedure rooms and clinics; 2) maintain and improve a centralized institution-wide tissue procurement and banking core facility that provides specimens according to NCI Best Practices for Biospecimen Resources and compatible with current, emerging, and anticipated methodologies for analysis of DNA, RNA and protein; 3) interface with other institutional databases to enhance the intranet-based database so it will provide epidemiology, family history, patient treatment, and patient outcome; 4) support the individual programmatically administered and funded satellite tissue banks operational within the institution, including those maintained by disease sites, SPOREs and P01s; and 5) meet the federal, state and institutional regulatory requirements for use of human tissue in research and protection of human subjects. The Facility occupies 379 sq ft and 187 sq ft within the two Surgical Pathology suites and has a separate 2,500 sq ft secure, monitored, environmentally-controlled facility with 21 freezers. Additional tissue processing rooms for TPBF use are located in each clinic with procedure rooms. The TPBF is staffed with a Director, Laboratory Manager, 2 Tissue Procurement Specialists, 2 Tissue Laboratory Assistants, a Data Coordinator, and a Clinical Research Coordinator. During the previous funding period, 154,122 specimens were collected from 21,902 cases. A total of 124,378 specimens were distributed with 87% provided to 14 peer-reviewed funded satellite banks, 5% to peer-reviewed funded individual investigators, 7% to non-peer reviewed funded individual investigators, and 1% to non-peer reviewed funded satellite banks. Individual investigators can obtain tissue specimens from satellite banks and the TPBF. TPBF services were used by 66 investigators from 19 of the 21 CCSG programs. 65% of the individual users had peer-reviewed funding and accounted for 40% of the utilization by individual users. Future plans are focused on interfacing with clinical, epidemiologic, tumor registry, and protocol databases to enhance specimen annotation through the TissueStation and ResearchStation software initiatives; quality control/quality assurance including evaluation with the Biospecimen Repository Evaluation Tool (BRET) from the National Cancer Institute; completion of compliance with the NCI Best Practices for Biospecimen Resources that were issued in June of 2007 and Clinical Laboratory Improvement Act of 1988, and continuing to expand capacity to meet research needs.