Early Alcohol Use Onset: Influence of Religion-Spirituality Dimensions

描述(申请人提供)：目的：增加对酒精使用的缓和影响的知识，特别是宗教-精神(R/S)维度以及潜在的遗传和环境效应对R/S酒精缓解的发生和发展的影响。在当前病因学模型的指导下，分析还将检查R/S对酒精使用障碍遗传风险假想中介因素的影响：行为控制不足和负面情绪调节。目的：(1)表征R/S维度和R/S-饮酒关联；(2)使用全表型模型表征R/S维度对早发和重度饮酒的主效应和交互效应；(3)估计R/S维度的遗传、共享和非共享环境贡献对R/S维度的方差和协方差及其与开始饮酒年龄和饮酒严重程度的相关性；(4)检验R/S维度对饮酒开始年龄和饮酒重度的遗传或共享环境效应的调节作用，并表征(基因x环境)调节效应。方法：二次数据分析将对现有的、已确定的数据进行分析，这些数据来自一项大规模前瞻性研究，研究对象是以前对密苏里州出生的青春期女性双胞胎及其家人进行的评估中的药物使用开始和进展以及相关的精神障碍。可用的R/S变量将允许在酒精中毒病因学的两个关键模型中检验R/S的五个维度的调节作用。相关性：研究结果将对(A)确定酒精中毒风险的媒介和调节因子的病因学努力，以及(B)经常观察到R/S对酒精中毒结局的治疗增强和保护作用的治疗和预防努力具有相当重要的意义。

DESCRIPTION (provided by applicant): Objective: To increase knowledge of moderating influences on alcohol use, specifically, religious-spiritual (R/S) dimensions and underlying genetic and environmental effects on R/S moderation of alcohol onset and progression. Guided by current etiological models, analyses will also examine R/S effects on the hypothesized mediators of genetic risk for alcohol use disorders: behavioral undercontrol and negative affect regulation. Aims: (1) characterization of R/S dimensionality and R/S-alcohol use association; (2) characterization, using full phenotypic models, of main and interactive effects of R/S dimensions on early onset and heavy alcohol use; (3) estimation of genetic, shared, and non-shared environmental contributions to the variance and covariance of R/S dimensions and to their correlations with age-at-onset of alcohol use and heaviness of alcohol use; (4) to test the role of R/S dimensions in moderating genetic or shared environmental effects on age-at-onset of alcohol use and heaviness of alcohol use, and to characterize moderating (genotype x environment) effects. Method: Secondary data analyses will be conducted on existing, deidentified data from a large-scale prospective research study of substance use onset and progression and associated psychiatric disorders from previous assessments of Missouri-born adolescent female twins and their families. Available R/S variables will permit examination of the moderating effects of five R/S dimensions within two key models of alcoholism etiology. Relevance: Resultant findings will be of considerable importance to (a) etiological efforts in characterizing the mediators and moderators of alcoholism risk, and to (b) treatment and prevention efforts that have frequently observed treatment enhancing and protective effects of R/S on alcoholism outcomes.