C3: Tissue and Histopathology

扩展我们对癌症生长和进展中的分子事件的理解需要详细的 分子特征与生物肿瘤行为和宿主反应的相关性这些数据是 对于设计新的、更有效的疗法、更好地应用传统疗法和 预防肿瘤复发的策略。一个基本的前提是可以获得完整的临床， 人口学和治疗数据与来自具有良好特征的人类的分子数据相集成 肿瘤和血清样本，以及我们独特的头颈部癌细胞系，这些细胞系在 用于研究新制剂或机制的体外和体内模型系统。来支持这项研究 UM-HN孢子计划、NCI和其他孢子计划的调查人员所做的努力，a 集组织采购、加工、储存、头颈癌细胞系库、配送于一体 提出了工艺和数据管理系统。这一核心代表了Basic 科学家、解剖病理学家、临床医生和数据管理员。它建立了我们以前收集的经验， 在我们的头颈部肿瘤学项目研究人员和 我们UM癌症中心组织和肿瘤采购核心的经验，以及与 嗯，前列腺孢子。全血、血清、鲜血的详细分配规则及标准化加工 适当包埋和冷冻保存的组织，RNA中的组织，石蜡包埋的组织， 内容包括免疫组织学、组织微阵列和细胞培养准备。详细的描述性说明 关系数据库，包括肿瘤特征、患者人口统计、健康行为、合并症 家族史、治疗和随访数据与肿瘤库数据和每个研究人员的 实验室由一个名为BioDBx的安全头颈部Web数据库提供，该数据库与临床 UM健康系统数据存储库(关怀网络)。提供灵活性以满足任何项目的特定需求 以及为未来的项目或与外部调查人员的合作纳入新技术。我们 我已经提出了一个模型系统，它将是一种最大限度地提高组织临床数据可用性的资源 以供整个NCI孢子界研究这些相对不常见的头颈部癌症。

Extending our understanding of the molecular events in cancer growth and progression requires detailed correlations of molecular characteristics with biologic tumor behavior and host response These data are essential to the design of new, more effective therapies, better application of conventional treatments and prevention strategies for tumor relapse. An essential prerequisite is availability of complete clinical, demographic, and treatment data that are integrated with molecular data from well-characterized human tumor and serum samples as well as our unique panel of head and neck cancer cell lines that serve as in vitro and in vivo model systems for investigation of novel agents or mechanisms. To support the research efforts of investigators in this UM-HN SPORE program, the NCI and other SPORE programs, a comprehensive tissue procurement, processing, storage, head and neck cancer cell line bank, distribution process and data management system is proposed. This core represents collaborative efforts of basic scientists, anatomic pathologists, clinicians and data managers. It builds our prior experience in collecting, storing and distributing tissues among our Head and Neck Oncology Program Investigators and the experience of our UM Cancer Center Tissue and Tumor procurement Core, as well as cooperation with the UM Prostate SPORE. Detailed distribution rules and standardized processing for whole blood, serum, fresh tissue with proper imbedding and frozen storage, tissue in RNA Later, paraffin embedded tissue, immunohistology, tissue microarray, and cell culture preparation are included. A detailed descriptive relational database including tumor characteristics, patient demographics, health behaviors, co-morbidities, family history, treatment and follow-up data is linked with the tumor repository data and each investigator's laboratory by a secure Head and Neck web-based database called BioDBx that is interfaced with the clinical UM Health System data repository (Care Web). Flexibility is provided to meet specific needs of any project and incorporation of new technologies for future projects or collaborations with outside investigators. We have proposed a model system that will be a resource that maximizes superb tissue-clinical data availability for studying these relatively uncommon head and neck cancers by the entire NCI SPORE community.