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C3: Tissue and Histopathology

C3：组织和组织病理学

基本信息

批准号：
7448856
负责人：
THOMAS E. CAREY
金额：
$ 14.94万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-07-01 至 2013-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7448856
关键词：
Aliquot Anatomy Antibodies Antigens Archives Bar Codes Basic Science Behavior Biological Biological Models Biopsy Biopsy Specimen Build-it Calibration Cancer Center Cancer cell line Caring Cell Line Cell Separation Cells Characteristics Cisplatin Clinical Clinical Data Clinical Trials Coagulation Process Collaborations Collection Communities Community Clinical Oncology Program Confidentiality of Patient Information Consent Consult Consultations Cultured Cells DNA DNA Fingerprinting Data Databases Decision Making Detection Development Diagnosis Diagnostic Ensure Equipment and supply inventories Event Excision Experimental Designs Experimental Models Family history of Fibrin Formalin Freezing Fresh Tissue Funding Future Gene Amplification Gene Dosage Gene Expression Gene Mutation Growth Head and Neck Cancer Head and Neck Surgeon Head and neck structure Health behavior Health system Histologic Histopathology Human Human Papillomavirus Image Immune response Immunohistochemistry In Situ Hybridization In Vitro Individual Information Systems Informed Consent Internet Investigation Knowledge Label Laboratories Laboratory Research Link Malignant Neoplasms Measures Messenger RNA Methodology Methods Michigan Microdissection Microsatellite Repeats Mitochondria Molecular Morbidity - disease rate Mutation Mycoplasma Nature Neck Dissection Neoplasm Metastasis Newly Diagnosed Normal tissue morphology Numbers Nurses Online Systems Operative Surgical Procedures Organ Outcome Paraffin Paraffin Embedding Pathologist Pathology Patient Care Patients Pilot Projects Pliability Population Preparation Prevention strategy Primary Neoplasm Process Prostate Publications Quality Control Quarantine RNA Radiation Tolerance Radiosurgery Range Reagent Records Recurrence Relapse Reproducibility Reproduction spores Research Research Ethics Committees Research Personnel Research Project Grants Resistance Resources Retrieval Review Committee Saliva Sampling Scientist Score Screening procedure Secure Serum Services Site Slide Small Interfering RNA Specimen Staining method Stains Standardization Support of Research Surgeon System TP53 gene Testing Therapeutic Time Tissue Microarray Tissue Procurements Tissues Translational Research Tumor Cell Line Tumor Tissue Universities Visit Whole Blood Wolves Work Writing austin base caregiving cell behavior cost data management demographics design established cell line experience follow-up head and neck cancer patient in vivo Model innovation interest knock-down knowledge base lymph nodes malignant mouth neoplasm new technology novel oncology programs repository research study response sample collection success tissue fixing tissue/cell culture tool tumor

项目摘要

Extending our understanding of the molecular events in cancer growth and progression requires detailed correlations of molecular characteristics with biologic tumor behavior and host response These data are essential to the design of new, more effective therapies, better application of conventional treatments and prevention strategies for tumor relapse. An essential prerequisite is availability of complete clinical, demographic, and treatment data that are integrated with molecular data from well-characterized human tumor and serum samples as well as our unique panel of head and neck cancer cell lines that serve as in vitro and in vivo model systems for investigation of novel agents or mechanisms. To support the research efforts of investigators in this UM-HN SPORE program, the NCI and other SPORE programs, a comprehensive tissue procurement, processing, storage, head and neck cancer cell line bank, distribution process and data management system is proposed. This core represents collaborative efforts of basic scientists, anatomic pathologists, clinicians and data managers. It builds our prior experience in collecting, storing and distributing tissues among our Head and Neck Oncology Program Investigators and the experience of our UM Cancer Center Tissue and Tumor procurement Core, as well as cooperation with the UM Prostate SPORE. Detailed distribution rules and standardized processing for whole blood, serum, fresh tissue with proper imbedding and frozen storage, tissue in RNA Later, paraffin embedded tissue, immunohistology, tissue microarray, and cell culture preparation are included. A detailed descriptive relational database including tumor characteristics, patient demographics, health behaviors, co-morbidities, family history, treatment and follow-up data is linked with the tumor repository data and each investigator's laboratory by a secure Head and Neck web-based database called BioDBx that is interfaced with the clinical UM Health System data repository (Care Web). Flexibility is provided to meet specific needs of any project and incorporation of new technologies for future projects or collaborations with outside investigators. We have proposed a model system that will be a resource that maximizes superb tissue-clinical data availability for studying these relatively uncommon head and neck cancers by the entire NCI SPORE community.

扩展我们对癌症生长和进展中的分子事件的理解需要详细的分子特征与生物学肿瘤行为和宿主反应的相关性这些数据是对于设计新的、更有效的治疗方法、更好地应用传统治疗方法以及肿瘤复发的预防策略。一个基本的先决条件是提供完整的临床，人口统计学和治疗数据与来自充分表征的人类的分子数据相结合，肿瘤和血清样本以及我们独特的头颈癌细胞系，用于研究新试剂或机制的体外和体内模型系统。为了支持这项研究研究人员在UM-HN SPORE计划、NCI和其他SPORE计划中的努力，全面的组织采购、加工、储存、头颈癌细胞系库、配送工艺和数据管理系统。这个核心代表了基本的科学家、解剖病理学家、临床医生和数据管理员。它建立了我们在收集，在我们的头颈肿瘤项目研究者和我们的UM癌症中心组织和肿瘤采购核心的经验，以及与 UM前列腺孢子。全血、血清、新鲜血液、适当包埋和冷冻保存的组织，RNA组织，石蜡包埋组织，包括免疫组织学、组织微阵列和细胞培养制备。详细的描述关系数据库，包括肿瘤特征、患者人口统计学、健康行为、共病，家族史、治疗和随访数据与肿瘤储存库数据和每个研究者的通过一个名为BioDBx的安全的头颈部网络数据库与临床实验室连接， UM Health System数据存储库（Care Web）。提供灵活性以满足任何项目的特定需求以及为未来的项目或与外部调查人员的合作引入新技术。我们我提出了一个模型系统，它将成为一种资源，最大限度地提高组织临床数据的可用性研究这些相对罕见的头颈部癌症的整个NCI孢子社区。