CENTRAL ADMINISTRATIVE CORE

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The Central Administrative Core is the coordinating and facilitating structure for the planning, development, and integration of Projects within the Center. This involves promoting communication among Project researchers and the individual components within the Center, thus taking full advantage of the interdisciplinary nature of the Center. The Central Administrative Core will provide administrative support, scientific and medical expertise, resource and support services (including recruitment, screening, urine toxicology) and support for pilot studies. The various components of the Central Administrative Core are described below: 1) Administrative and support service component: centralized coordination and support services, including advertising, recruitment and screening, for the overall Center and major Projects. 2) Research facilities component: library facilities, facilities and support for all urine toxicology and analytical chemistry, support of at least three inpatient beds and on the General Clinical Research Services located in the New York State Psychiatric Institute (NYSPI) for Project 1 (Laboratory Model for Heroin Abuse Medications), support of the Human Laboratory Facility located on the NIH-funded Irving Center for Clinical Research (ICCR) of Columbia University/Presbyterian Hospital for Project 2 (Mesolimbic DA D l/D2 Receptors and Response to Cocaine), support of the Opioid Self-administration Laboratory for Project 1, support of laboratory testing rooms in the Biological Studies Unit (BSU) and outpatient testing rooms within the Substance Use Research Center (SURC) for Project 5 (Pharmacological Treatment of Marijuana Dependence) and pilot studies, support of inpatient residential studies using the Residential Laboratory of the SURC for Project 5 and support of all clinical treatment studies (see below). 3) Clinical component: The clinical component supports an outpatient Substance Treatment Research Service (STARS) to provide: 1) initial recruitment and screening for all studies in the Center, as well as additional assessments for all treatment pilot studies and Project 3 (New Approaches to Cocaine Abuse Medications) and Project 4 (Agonist Treatment of Marijuana Dependence); 2) HIV risk assessment and counseling for all studies in the Center; and 3) psychotherapy/counseling for Projects 3 and 4, as well as all treatment pilot studies. Projects 3 and 4, as well as and any treatment pilot studies will be carried out at STARS and our new site Project Outreach in Long Island. 4) Research support component: support of pilot studies and research projects to be conducted by young faculty members and research fellows. These pilot studies have been an extraordinarily productive aspect of this MDRC since its inception.