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Non-coding RNAs involved in HIV-1 Latency

Non-coding RNAs involved in HIV-1 Latency
与 HIV-1 潜伏期相关的非编码 RNA
批准号：
7837353
负责人：
Kevin V Morris
金额：
$43.74万
依托单位：
SCRIPPS RESEARCH INSTITUTE, THE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-09-23 至 2011-08-31
来源：
https://reporter.nih.gov/project-details/7837353
关键词：
Antisense RNACD4 Positive T LymphocytesCell Cycle StageDevelopmentEpigenetic ProcessFunctional RNAGene Expression RegulationGenerationsGenetic TranscriptionHIVHIV-1MediatingMolecular ProfilingMolecular TargetPathway interactionsProteinsRegulationRestRoleSmall Interfering RNASocietiesSystemTestingTherapeuticTranscriptVaccine DesignViralVirus DiseasesVirus Latencyaptamerbasecell typelatent virus activationpromoterpurgetherapeutic vaccinetranscription factor

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中文摘要
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英文摘要
This project will characterize and develop the ability to transcriptionally modulate HIV-1 latency. We have recently discovered that antisense non-coding RNAs can regulate gene transcription and evidence suggests that HIV-1 also utilizes this mechanism to regulate latency. We will determine the underlying mechanism of action involved in antisense non-coding RNA regulation of viral latency and the ability to use this form of gene regulation to control HIV-1 expression. Results from this project will result in a paradigm shift with regards to controlled expression of HIV-1 that could prove valuable to society with regards to new anti-HIV therapeutics and vaccine design. 1
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  • 项目类别：
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  • 财政年份：
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  • 依托单位：
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  • 项目类别：
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  • 财政年份：
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  • 负责人：
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  • 依托单位：
    SCRIPPS RESEARCH INSTITUTE, THE