Nicotine competition with light control of conditioned responding

尼古丁与条件反应光控制的竞争

• 批准号: 7649464
• 负责人: Jennifer E Murray
• 金额: $ 1.79万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2009-10-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7649464
• 关键词: Accounting; Affect; Behavior; Behavior Therapy; Cessation of life; Characteristics; Cigarette; Conditioned Stimulus; Consumption; Cues; Discrimination; Dose; Elements; Employee Strikes; Environment; Feeling; Flavoring; Food; Goals; Health; Health Care Costs; Human; Indium; Individual; Infusion procedures; Injection of therapeutic agent; Intravenous infusion procedures; Light; Lung; Maintenance; Methods; Nicotine; Nicotine Dependence; Pharmaceutical Preparations; Pharyngeal structure; Physiological Effects of Drugs; Play; Process; Property; Publishing; Rattus; Relapse; Relative (related person); Research; Role; Self Perception; Smoker; Stimulus; Sucrose; Techniques; Testing; Therapeutic; Time; Tobacco; Tobacco use; Training; United States; Visual; classical conditioning; conditioning; drinking; drug of abuse; drug relapse; experience; follow-up; interest; irritation; nicotine craving; novel strategies; peer; premature; research study; response; smoking cessation; sound; success; treatment strategy; visual stimulus

DESCRIPTION (provided by applicant): The physiological effects of drugs of abuse form associations with other stimuli present in the environment in which the drug is experienced. These associations play an integral role in the acquisition, maintenance, and relapse of drug-taking behavior. In human tobacco users nicotine is experienced in the presence of a variety of other stimuli. These other stimuli are often the object of behavioral treatments for smoking cessation. Therefore, a better understanding how nicotine interacts with other stimuli for control of a conditioned response may assist smoking cessation behavioral treatment strategies. The goal of the present proposal is to systematically examine cue competition between a discrete interoceptive nicotine CS and an exteroceptive light CS in an appetitive Pavlovian discrimination task. In Specific Aim 1 we will determine whether nicotine overshadowing of the light is dependent on nicotine dose. Rats will be trained using a compound stimulus in which the concurrent intravenous infusion of nicotine and a light presentation will be reliably followed by a brief sucrose delivery. Overshadowing will be determined by the relative control of conditioned responding by each of the elements when they are tested separately. We will also examine the blocking phenomenon between the exteroceptive light and interoceptive nicotine CSs. In Specific Aim 2, rats will be trained with either nicotine or the light paired reliably with the sucrose delivery. After acquisition of the conditioned response, the other element (i.e., nicotine infusion or light) will be added to create the compound conditioned stimulus. Again, rats will then be tested for control of conditioned responding to each element separately. We expect that the stimulus that is first paired with sucrose will block conditioned responding to the subsequently added stimulus. The findings of the proposed research will fill an important gap in our understanding of associative learning processes involving nicotine and may assist smoking cessation behavioral treatment strategies.

描述(由申请人提供)：滥用药物的生理效应与药物所处环境中存在的其他刺激有关。这些联系在吸毒行为的获得、维持和复发过程中发挥着不可或缺的作用。在人类烟草使用者中，尼古丁是在各种其他刺激的存在下体验到的。这些其他刺激通常是戒烟行为治疗的对象。因此，更好地了解尼古丁如何与其他刺激相互作用以控制条件反应，可能有助于戒烟行为治疗策略。本研究的目的是系统地研究在食欲巴甫洛夫辨别任务中，离散的内感型尼古丁CS和外感型光CS之间的线索竞争。在特定的目标1中，我们将确定尼古丁对光线的遮蔽是否依赖于尼古丁剂量。大鼠将使用复合刺激进行训练，在复合刺激中，同时静脉注射尼古丁和轻微的表现将可靠地随后是短暂的蔗糖注射。遮蔽将由每个元素在单独测试时对条件反应的相对控制来确定。我们还将研究外部感受性光和内部感受性尼古丁CS之间的阻断现象。在特定的目标2中，大鼠将接受尼古丁或与蔗糖输送可靠配对的光线的训练。在获得条件反应后，另一种元素(即尼古丁输注或光线)将被添加以产生复合条件刺激。同样，随后将分别测试老鼠对每个元素的条件性反应的控制性。我们预计，最初与蔗糖配对的刺激将阻止对随后添加的刺激的条件性反应。这项拟议的研究结果将填补我们对尼古丁相关联想学习过程的一个重要空白，并可能有助于戒烟行为治疗策略。