CORE 2 DB5: PROTEOLYTIC PATHWAYS IN ACUTE VASCULAR RESPONSE

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Driving Biological Project 5: Proteolytic Pathways in Acute Vascular Response . Maintenance of vascular network is crucial to all mammals. We will test the hypothesis that protease-dependent post-translational pathways regulate the maintenance (homeostasis) of vascular networks. The major components of the vasular network are endothelial cells, vascular smooth muscle cells (VSMCs or mural cells) and extracellular matrix (ECM) molecules. Under homeostatic conditions, networks are maintained in a quiescent state; however, following physiologic or pathologic stimulation, innate programs are rapidly inactivated/activated fostering vascular remodeling. One consequence of these events is vasodilation, and subsequent leakage of plasma proteins into interstitium. We plan to investigate the proteolytic pathways involved in this acute vascular response