Integrated Training in Quantitative and Experimental Cancer Systems Biology

项目摘要 迫切需要一支受过深入培训的、在数量上成熟的肿瘤学家国家骨干队伍 在癌症的生物学方面和计算工具，以进一步了解和治疗。在 根据拟议的培训计划，OHSU将利用其癌症计划的优势，从基本的 科学到翻译，以及它的计算能力，从基因组学到机械建模。OHSU 最近被自然指数评为世界上生命科学研究最年轻的大学。一个关键 培训计划的强度将需要定量和湿实验室基础或临床共同指导 教师。具有生物学或计算专业知识的博士后学员将获得广泛的 补充领域的培训，包括教学和研究。研究生学员将从事这两个领域 从第一天起，在现有课程和既定教师专业知识的基础上， 以生物医学工程系和细胞、发育与癌症系为中心 生物学培训教师在指导和研究生产力方面有着出色的记录， 由一个健康的青年教师队伍的补充，以保持长期计划的可行性。近40 最初将向受训人员提供教员，平均每年的研究经费超过80万美元。

Project Summary There is an outstanding need for a national cadre of quantitatively sophisticated oncologists, with deep training in both biological aspects of cancer and computational tools to further understanding and treatment. In the proposed training program, OHSU will leverage the strengths of both its cancer program, ranging from basic science to translation, and its computational capacity, spanning from genomics to mechanistic modeling. OHSU was recently ranked as the top young university in life sciences research in the world in the Nature Index. A key strength of the training program will be required co-mentorship by both quantitative and wet-lab basic or clinical faculty. Post-doctoral trainees arriving with expertise in either biology or computation will receive extensive training in the complementary field, both didactic and research-based. Graduate trainees will engage both fields from day one in a specially designed curriculum building on existing courses and established faculty expertise, centered in the Departments of Biomedical Engineering and the Department of Cell, Developmental & Cancer Biology. The training faculty have outstanding track records in mentorship and research productivity, complemented by a healthy cohort of junior faculty to maintain program viability over the long term. Nearly 40 faculty will initially be available to trainees, with an average of >$800,000/year in research funding.