Integrated Training in Quantitative and Experimental Cancer Systems Biology

项目摘要 迫切需要一支受过深度培训、在数量上成熟的肿瘤学家组成的国家干部队伍。 在癌症的生物学方面和计算工具方面，以进一步了解和治疗。在 拟议的培训计划，OHSU将利用其癌症计划的优势，从基础 从科学到翻译及其计算能力，从基因组学到机械建模。OHSU 最近在自然指数中被评为世界上最年轻的生命科学研究大学。一把钥匙 培训计划的强度将需要定量和湿法实验室的共同指导-基础或临床 教职员工。具有生物学或计算专业知识的博士后实习生将获得广泛的 补充性领域的培训，既有教学培训，也有研究培训。毕业实习生将同时从事这两个领域。 从第一天开始，在现有课程和现有教师专业知识的基础上，特别设计的课程大楼， 以生物医学工程系和细胞、发育和癌症系为中心 生物学。培训教师在指导和研究效率方面有着出色的记录， 辅以一支健康的初级教员队伍，以保持项目的长期可行性。将近40岁 教员最初将向学员开放，平均每年有80万英镑的研究经费。

Project Summary There is an outstanding need for a national cadre of quantitatively sophisticated oncologists, with deep training in both biological aspects of cancer and computational tools to further understanding and treatment. In the proposed training program, OHSU will leverage the strengths of both its cancer program, ranging from basic science to translation, and its computational capacity, spanning from genomics to mechanistic modeling. OHSU was recently ranked as the top young university in life sciences research in the world in the Nature Index. A key strength of the training program will be required co-mentorship by both quantitative and wet-lab basic or clinical faculty. Post-doctoral trainees arriving with expertise in either biology or computation will receive extensive training in the complementary field, both didactic and research-based. Graduate trainees will engage both fields from day one in a specially designed curriculum building on existing courses and established faculty expertise, centered in the Departments of Biomedical Engineering and the Department of Cell, Developmental & Cancer Biology. The training faculty have outstanding track records in mentorship and research productivity, complemented by a healthy cohort of junior faculty to maintain program viability over the long term. Nearly 40 faculty will initially be available to trainees, with an average of >$800,000/year in research funding.