Molecular dissection of the dengue virus NS1 protein

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Over half of the world’s population is at risk of infection with pathogenic flaviviruses such as dengue virus (DENV) and Zika virus (ZIKV). Unfortunately there are no antiviral therapies or safe and effective vaccines. In this project we will employ advanced genomics, sensing and imaging techniques to reveal new details about the exact functions and interactions of the multifunctional viral NS1 protein. This understanding will expedite development of antiviral strategies directed against NS1.