A PILOT STUDY ON TREATMENT EFFECT OF TOMATO LYCOPENE AND SOY ISOFLAVONES ON

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 番茄红素衍生物还显示出增加细胞培养物中的胰岛素敏感性，并改善2型糖尿病动物模型和肥胖和瘦Zucker大鼠中的胰岛素抵抗。口服番茄红素对人体外周胰岛素敏感性的影响尚不清楚。 我们假设番茄红素和/或大豆异黄酮可以提高胰岛素降低血糖的能力。本研究的目的是测量用含有番茄红素、大豆异黄酮或两者的组合的片剂治疗12周对胰岛素降低血糖的能力的影响。我们将邀请健康志愿者参与本研究。每个志愿者都有皮肤褶皱测量，以估计体内的脂肪含量。体重和身高也将在入院时测量。第二天早上，经过一夜的禁食，每位志愿者将进行一项名为正常血糖-高胰岛素钳夹的测试。这项测试可以测量胰岛素在降低血糖方面的作用。然后，我们将给志愿者一粒含有番茄红素的胶囊，番茄红素，番茄红素和番茄红素酮的两种或两种不同胶囊的预混物（未预混）。在12周结束时，每位志愿者将再次接受与首次入院时相同的测试。如果我们的研究证实番茄红素和/或大豆异黄酮可以提高胰岛素降低血糖的能力，这种治疗方法可以用于有糖尿病风险或已经患糖尿病的人。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Lycopene derivative has been also shown to increase insulin sensitivity in cell cultures and improve insulin resistance in animal models of type 2 diabetes and in obese and lean Zucker rats. Data about the effect of oral administration of lycopene on peripheral insulin sensitivity in human is still unknown. We hypothesize that Lycopene and/or soy isoflavones can improve the ability of insulin to lower blood sugar. The objective of this study is to measure the effect of 12 weeks treatment with tablets containing Tomato Lycopene, Soy Isoflavones or a combination of the two, on the ability of insulin to lower blood sugar. We will ask healthy volunteers to participate in this study. Each volunteer and have skinfolds measured to estimate content of fat in the body. Weight and height will also be measured during the admission. In the morning, after overnight fast, each volunteer will have a test called euglycemic-hyperinsulinemic clamp. This test allows measuring how well insulin works in decreasing blood sugar. We will then give the volunteer either a capsule that contains lycopene, isoflavone, a premix of the two or 2 different capsules with lycopene and isoflavones (not pre-mixed). At the end of 12 weeks each volunteer will again be given the same tests done on first admission. If our study confirms that tomato lycopene and/or soy isoflavones can improve the ability of insulin to lower blood sugar, this treatment could be used in persons who are at risk or who have already developed diabetes.