STRUCTURAL NEUROIMAGING OF EARLY ONSET/ADOLESCENT BPD

早发/青少年 BPD 的结构神经影像

• 批准号: 7953708
• 负责人: Marc T Goodman
• 金额: $ 0.37万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7953708
• 关键词: Adolescent; Adult; Age; Amygdaloid structure; Anterior; Area; Borderline Personality Disorder; Cerebrum; Child; Clinical Research; Communities; Computer Retrieval of Information on Scientific Projects Database; Disease; Dorsal; Early identification; Exhibits; Funding; Grant; Institution; Lateral; Magnetic Resonance Imaging; Mental Health; Methods; Neurobiology; Patients; Population; Prefrontal Cortex; Prevention; Protocols documentation; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Ventricular; aged; brain volume; cingulate gyrus; early onset; emotion regulation; frontal lobe; gray matter; meetings; neuroimaging; treatment strategy

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 9/18/2007 Borderline Personality Disorder (BPD) is a disabling disorder characterized by poor emotion regulation and poor impulse control. The disorder remains notoriously difficult to treat effectively, with many patients responding poorly or partially even to the most widely accepted treatment strategies. For these reasons, developing methods of early identification and prevention of BPD is an urgent priority for the mental health community. This study will focus on early-onset BPD and study older children and adolescents who meet criteria for BPD, in efforts to begin to characterize the underlying neurobiology of the disorder in earlier age populations using magnetic resonance imaging. Aims: (Protocol, Page 3) 1. To examine structural differences in total brain volume, total cerebrum volume, ventricular volume, cortical gray matter, particular areas of the prefrontal cortex including anterior cingulate gyrus, orbital frontal cortex and dorsal lateral prefrontal cortex, and amygdala in adolescents aged 15-18, meeting criteria for BPD compared to normal control adolescents. 2. To investigate whether adolescents with BPD demonstrate similar abnormal findings seen in adult BPD including specific reductions in gray matter volume in ACC (BA 24). Hypotheses: (Protocol, Page 3) 1. Adolescents with BPD will exhibit reductions in ACC but have total brain volumes, ventricular and cerebrum volumes similar to normal control adolescents. 2. Amygdalar volumes in adolescent BPD will not differ from normal control adolescents.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 9/18/2007 边缘型人格障碍（BPD）是一种以情绪调节能力差和冲动控制能力差为特征的致残性障碍。 众所周知，这种疾病仍然难以有效治疗，许多患者甚至对最广泛接受的治疗策略反应不佳或部分反应。 由于这些原因，开发早期识别和预防BPD的方法是精神卫生界的当务之急。 本研究将重点关注早发性BPD，并研究符合BPD标准的年龄较大的儿童和青少年，努力开始使用磁共振成像来描述早期人群中该疾病的潜在神经生物学特征。 目的：（方案，第3页） 1.研究15-18岁符合BPD标准的青少年与正常对照青少年相比在总脑体积、总大脑体积、脑室体积、皮质灰质、前额叶皮质特定区域（包括前扣带回、眶额叶皮质和背外侧前额叶皮质）和杏仁核的结构差异。 2.研究青少年BPD患者是否表现出与成人BPD相似的异常结果，包括ACC中灰质体积的特异性减少（BA 24）。 假设：（方案，第3页） 1.患有BPD的青少年将表现出ACC减少，但总脑体积、脑室和大脑体积与正常对照青少年相似。 2.青少年BPD患者的扁桃体体积与正常对照青少年没有差异。