TEDDY

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 1型糖尿病（T1 DM）是儿童最常见和最严重的慢性疾病之一，特别是在非常年轻的儿童中。 该病的病因尚不清楚。 T1 DM的易感性有很大的遗传因素。高风险HLA II类等位基因似乎贡献了40-45%的遗传风险，其他基因已被鉴定为提供更适度的风险贡献。 在一般人群中，只有约1/15的具有高风险HLA等位基因的儿童和15的具有1型糖尿病一级亲属和高风险HLA的儿童会发展为T1 DM。 流行病学模式表明，病毒、营养、有毒物质或社会经济心理因素可能单独或联合起作用。 已证明难以连续识别诱发T1 DM的环境因素。 这项由NIH资助的TEDDY研究的长期目标是确定在遗传易感个体中触发或预防T1 DM的感染、饮食或其他环境暴露和心理因素。 我们将研究从出生开始，来自普通人群的高危儿童和T1 DM患者的亲属暴露于候选环境因素。 美国（佛罗里达/格鲁吉亚、科罗拉多、华盛顿州）、芬兰、瑞典和德国的6个中心将对20多万名新生婴儿进行筛查。识别这些因素将有助于更好地了解T1 DM的病因，并可能导致预防，延迟或逆转T1 DM的新策略。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Type 1 diabetes mellitus (T1DM) is one of the most common and serious chronic diseases in children, particularly in the very young. The etiology of the disease remains unclear. There is a substantial genetic component to susceptibility to T1DM. High risk HLA class II alleles appears to contribute 40-45% of genetic risk and other genes have been identified as providing more modest contributions to risk. Only about 1 in 15 children in the general population with the high risk HLA alleles and one in five with a first degree relative with type 1 diabetes and with the high risk HLA will develop T1DM. Epidemiologic patterns suggest that viruses, nutrition, toxic agents or socioeconomic psychosocial factors may contribute alone or in combination. Definitive identification of environmental factors that precipitate T1DM has proven difficult. The long-term goal of this NIH-funded TEDDY study is the identification of infectious, dietary, or other environmental exposures and psychological factors which trigger or prevent T1DM in genetically susceptible individuals. We will study from birth, high-risk children from the general population and relatives of people with T1DM for exposures to candidate environmental factors. Over 200,000 newborn babies will be screened by 6 centers in the US (Florida/Georgia, Colorado, Washington state), Finland, Sweden and Germany. Identification of such factors will lead to a better understanding of the cause of T1DM and could result in new strategies to prevent, delay, or reverse T1DM.