THE ROLE OF FATTY ACID COMPOSITION IN ANTI-EPILEPTIC EFFECTS OF THE KETOGENIC

脂肪酸组成在生酮抗癫痫作用中的作用

• 批准号: 7950896
• 负责人: John N. Clore
• 金额: $ 0.84万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950896
• 关键词: American; Antiepileptic Agents; Body fat; Cell membrane; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Diet; Epilepsy; Fatty Acids; Funding; Grant; Incidence; Institution; Intervention; Ketoses; Ketosis; Membrane; Overweight; Patients; Plasma; Plasma Cells; Protocols documentation; Research; Research Personnel; Resources; Role; Seizures; Source; Time; United States National Institutes of Health; cohort; ketogenic diet; ketogentic; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The hypothesis of this protocol is that changes in fatty acid composition induced by the ketogenic diet are correlated to a reduction in seizure incidence. The Specific Aims include: 1. To determine the fatty acid composition in plasma and in circulating cell membranes in a cohort of epilepsy patients before and after initiation of the KD. 2. To evaluate whether the fatty acid content of the KD correlates with the changes seen in the fatty acid content of the plasma cell membranes. 3. To determine whether the fatty acid content of PM changes with time on the diet. 4. To evaluate the fatty acid content of the KD and compare this to fatty acid content of the pre-intervention diet. 5. To determine if changes in fatty acid composition of plasma membranes differ between lean vs overweight subjects pre and post kd. To determine if body fat content correlates with time to ketosis or response level. 6. To determine whether the 4:1 ratio KD is maintained over the course of 1 year and whether or not the fa of the diet and the membranes remain consistent over time. 7. To evaluate the FA content of the KD and to compare this to the FA content of a typical American diet.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该方案的假设是生酮饮食诱导的脂肪酸组成变化与癫痫发作发生率降低相关。 具体目标包括： 1. 确定KD开始前后一组癫痫患者血浆和循环细胞膜中的脂肪酸组成。 2. 评价KD的脂肪酸含量是否与浆细胞膜脂肪酸含量变化相关。 3. 确定PM的脂肪酸含量是否随饮食时间而变化。 4. 评估KD的脂肪酸含量，并将其与干预前饮食的脂肪酸含量进行比较。 5. 确定kd前后瘦与超重受试者质膜脂肪酸组成的变化是否不同。 确定体脂含量是否与酮症时间或反应水平相关。 6. 确定在1年的过程中是否保持4：1的KD比例，以及饲料和膜的fa是否随时间保持一致。 7. 评估KD的FA含量，并将其与典型美国饮食的FA含量进行比较。