INFLUENZA-SPECIFIC HUMORAL AND CELLULAR IMMUNITY AFTER VACCINATION IN RECIPIENTS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 异基因造血干细胞移植（HSCT）或自体HSCT后对流感疫苗接种的免疫应答尚不清楚。 移植后季节性疫苗接种的最佳时间尚未确定。 此外，人们对免疫重建过程中的记忆反应知之甚少。 在造血重建期间定义体液和细胞免疫应答将允许更好地管理HSCT患者，并保护这些免疫功能低下的患者免受流感感染的发病。 在该患者人群中进行的研究将更好地了解对流感疫苗的免疫反应，从而深入了解保护整个人群免受可能的流感大流行的策略。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The immunological response to vaccination against influenza after allogeneic hematopoietic stem cell transplantation (HSCT) or autologous HSCT is not well understood. The optimal time for seasonal vaccination post transplant has not been defined. Further, very little is understood about the memory response during immune reconstitution. Defining both the humoral and cellular immune response during hematopoietic reconstitution would allow better management of HSCT patients and protect these immuno-compromised patients against the morbidity of influenza infection. Studies in this patient population will yield a better understanding of the immune response to the influenza vaccine, giving insight into strategies to protect the overall population from a possible influenza pandemic.