RHESUS CMV INFECTION OF IMMUNOSUPPRESSED CMV NATIVE RHESUS MONKEYS

免疫抑制 CMV 本地恒河猴的恒河猴 CMV 感染

• 批准号: 7959091
• 负责人: Don J Diamond
• 金额: $ 3.56万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959091
• 关键词: California; Computer Retrieval of Information on Scientific Projects Database; Cytomegalovirus; Funding; Goals; Grant; Human; Immunosuppression; Immunosuppressive Agents; Infection; Institution; Kinetics; Macaca; Macaca mulatta; Pilot Projects; Primates; Research; Research Personnel; Resources; Source; Transplant Recipients; Treatment Protocols; United States National Institutes of Health; Vaccines; design; immunosuppressed; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This pilot project is designed to evaluate the parameters of rhesus cytomegalovirus (RhCMV) under immunosuppressive conditions that reflect the state of immunosuppression in human transplant recipients. The goal of this study is to characterize the kinetics of RhCMV replication in immunosuppressed macaques to as a necessary prerequisite to subsequent studies that will evaluate vaccine regimens that would prevent RhCMV replication during immunosuppression.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该试验项目旨在评估免疫抑制条件下恒河猴巨细胞病毒（RhCMV）的参数，以反映人类移植受者的免疫抑制状态。 本研究的目的是表征免疫抑制猕猴中RhCMV复制的动力学，以作为后续研究的必要前提，这些研究将评估在免疫抑制期间预防RhCMV复制的疫苗方案。