CALIFORNIA NEUROAIDS TISSUE NETWORK (AIDS)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 CNTN的USC部分旨在识别、招募、招募和评估70名预期寿命不到一年的艾滋病患者，其中约12人每年将接受尸检。组织样本将从12-15例非神经损伤后死亡的对照病例中获得，将在5年内被送到组织储存库。首席研究员和一名神经学家将执行该项目所需的临床程序，并监督一名执行神经心理评估的研究助理。一名神经病理学家和病理助理(院长)将进行神经尸检，并在家人允许的情况下协助进行一般尸检。南加州大学的调查人员将把数据和标本传输到位于USCD的CNTN管理和数据中心和Brain Bank，后者将通过培训和监测提供数据管理、组织存储、网络站点之间的协调以及对项目所有方面的质量控制。参与者的招募将集中在拉丁美洲和加勒比南加州大学兰德·施拉德艾滋病毒？艾滋病诊所，该诊所估计有2650名艾滋病患者。研究对象将在死亡或失去后续行动时被替换。这些患者将每六个月接受一次结构化的医学、神经学、神经心理学、免疫学和病毒学评估，直到他们死亡。如果受试者在洛杉矶县医院内死亡，将在该医院进行尸检，或者他们将被转移到诺里斯癌症研究医院。所有尸检将在死亡后12小时内进行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The USC component of the CNTN is designed to identify, recruit, enroll, and assess a cohort of 70 AIDS patients with life expectancies of less than one year of whom about 12 will be autopsied each year. Tissue samples will be obtained from 12-15 control cases dying after non-neurologic trauma will be sent to the tissue repository bank over 5 years. The principal investigator and a neurologist will perform the clinical procedures required of the project and oversee a research assistant who will perform the neuropsychocologic assessments. A neuropathologist and pathology assistant (deanor) will conduct the neurologic autopsy and assist in the performance of the general autopsy when permitted by the family. The USC investigators will transmit data and specimens to the CNTN Administrative and Data Center and Brain Bank at USCD, which will provide data management, tissue storage, coordination among network sites, and quality control of all aspects of the project through training and monitoring. Recruitment of participants will will be focused at the LAC+USC Rand Schrader HIV?AIDS Clinic which follows an estimated 2,650 AIDS Patients. Research Subjects will be replaced as they die or are lost to follow up. These patients will undergo structured Medical, neurologic, neuropsychologic, immunocologic, and virologic assessments every six months until they die. Postmortem will be conducted at the LA County Hospital if the subject dies within that facility or they will be transferred to the Norris Cancer Research Hospital. All post mortem examinations will be conducted within 12 hours of death.