CALIFORNIA NEUROAIDS TISSUE NETWORK (AIDS)

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 CNTN的USC部分旨在识别，招募，登记和评估70名预期寿命不到一年的艾滋病患者的队列，其中每年约有12人将进行尸检。 将从12-15例非神经创伤后死亡的对照病例中获得组织样本，并在5年内将其送至组织储存库。 主要研究者和神经科医生将执行项目所需的临床程序，并监督将执行神经心理学评估的研究助理。 神经病理学家和病理学助理（deeper）将进行神经系统尸检，并在家属允许的情况下协助进行一般尸检。 南加州大学的研究人员将把数据和标本传输到CNTN行政和数据中心以及南加州大学的脑库，后者将通过培训和监测提供数据管理、组织储存、网络站点之间的协调以及项目各个方面的质量控制。 参与者的招募将集中在LAC+USC兰德施拉德艾滋病毒？艾滋病诊所，跟踪估计2 650名艾滋病患者。 研究受试者死亡或失访时将被替换。 这些患者将每六个月接受一次结构化的医学、神经学、神经心理学、免疫学和病毒学评估，直到他们死亡。 如果受试者在洛杉矶县医院死亡，将在该医院进行尸检，或者将其转移至诺里斯癌症研究医院。 所有尸检将在死亡后12小时内进行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The USC component of the CNTN is designed to identify, recruit, enroll, and assess a cohort of 70 AIDS patients with life expectancies of less than one year of whom about 12 will be autopsied each year. Tissue samples will be obtained from 12-15 control cases dying after non-neurologic trauma will be sent to the tissue repository bank over 5 years. The principal investigator and a neurologist will perform the clinical procedures required of the project and oversee a research assistant who will perform the neuropsychocologic assessments. A neuropathologist and pathology assistant (deanor) will conduct the neurologic autopsy and assist in the performance of the general autopsy when permitted by the family. The USC investigators will transmit data and specimens to the CNTN Administrative and Data Center and Brain Bank at USCD, which will provide data management, tissue storage, coordination among network sites, and quality control of all aspects of the project through training and monitoring. Recruitment of participants will will be focused at the LAC+USC Rand Schrader HIV?AIDS Clinic which follows an estimated 2,650 AIDS Patients. Research Subjects will be replaced as they die or are lost to follow up. These patients will undergo structured Medical, neurologic, neuropsychologic, immunocologic, and virologic assessments every six months until they die. Postmortem will be conducted at the LA County Hospital if the subject dies within that facility or they will be transferred to the Norris Cancer Research Hospital. All post mortem examinations will be conducted within 12 hours of death.