EVAL OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS AND ADRENOMEDULLARY FUNCTION

下丘脑-垂体-肾上腺轴和肾上腺髓质功能的评估

• 批准号: 7982157
• 负责人: MITCHELL GEFFNER
• 金额: $ 2.2万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7982157
• 关键词: Adrenal Glands; Affect; CRH gene; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Corticotropin; Disease; Epinephrine; Funding; Glucocorticoids; Grant; Hydrocortisone; Institution; Measures; Metanephrine; Patients; Pharmaceutical Preparations; Plasma; Research; Research Personnel; Resources; Simulate; Source; Stress; United States National Institutes of Health; hypothalamic-pituitary-adrenal axis; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In patients with non classical adrenal hyperlasia, the hypothalamic-pituitary-adrenal axis is midly affected by the disease and only minimally further suppressed by the administration of glucocorticoid medication. It is unknown whether adrenomedullary function is also compromised in these patients. We hypothesize that these patients can mount an appropriate endogenous cortisol response to stress and that their adrenomedullary function is intact. The study purpose is: 1; To examine ACTH and cortisol responses under stress ;simulated by CRH administration& in patients with NCAH, 2; To measure plasma total metanephrine, free metanephrine, and epinephrine under similar stress conditions, 3; To extrapolate from thse findings as to whether glucocorticoid coverage during periods of stress is necessary for patients with NCAH.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 在患有非经典肾上腺增生症的患者中，下丘脑-垂体-肾上腺轴受到该疾病的中度影响，并且仅通过糖皮质激素药物的施用而得到最小程度的进一步抑制。 目前尚不清楚这些患者的肾上腺髓质功能是否也受到损害。 我们假设这些患者可以对压力产生适当的内源性皮质醇反应，并且他们的肾上腺髓质功能完好无损。 研究目的是：1；检查 NCAH 患者在压力下的 ACTH 和皮质醇反应；通过 CRH 给药模拟；2；测量类似应激条件下的血浆总变肾上腺素、游离变肾上​​腺素和肾上腺素，3；根据这些发现推断 NCAH 患者在压力期间是否需要使用糖皮质激素。