EVAL OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS AND ADRENOMEDULLARY FUNCTION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在非经典肾上腺增生症患者中，下丘脑-垂体-肾上腺轴受到疾病的中度影响，并且仅在给予糖皮质激素药物后受到最小程度的进一步抑制。 目前尚不清楚这些患者的肾上腺髓质功能是否也受到损害。 我们假设这些患者可以对应激产生适当的内源性皮质醇反应，并且他们的肾上腺髓质功能是完整的。 研究目的是：1个;检查应激下ACTH和皮质醇的反应;模拟CRH管理和NCAH患者，2;在类似的应激条件下测量血浆总代谢产物，游离代谢产物和肾上腺素，3;从这些发现推断应激期间糖皮质激素的覆盖是否对NCAH患者是必要的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In patients with non classical adrenal hyperlasia, the hypothalamic-pituitary-adrenal axis is midly affected by the disease and only minimally further suppressed by the administration of glucocorticoid medication. It is unknown whether adrenomedullary function is also compromised in these patients. We hypothesize that these patients can mount an appropriate endogenous cortisol response to stress and that their adrenomedullary function is intact. The study purpose is: 1; To examine ACTH and cortisol responses under stress ;simulated by CRH administration& in patients with NCAH, 2; To measure plasma total metanephrine, free metanephrine, and epinephrine under similar stress conditions, 3; To extrapolate from thse findings as to whether glucocorticoid coverage during periods of stress is necessary for patients with NCAH.