BARRIERS TO EFFECTIVE WEIGHT LOSS IN OVERWEIGHT ADOLESCENTS ENROLLED IN AN IN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项试验的基本假设是通过口服自身抗原(胰岛素)来诱导对胰岛素分泌β细胞的免疫耐受的概念。 主要结果是那些登记在主要分析队列中的人从随机分配治疗到发展为糖尿病所经过的时间。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The underlying hypothesis of this trial is the concept of induction of immunologic tolerance to the insulin secreting beta cell through the presentation of the autoantigen (insulin) orally. The primary outcome is the elapsed time from random treatment assignment to the development of diabetes among those enrolled in the primary analysis cohort.