CLINICAL RESEARCH INFRASTRUCTURE

临床研究基础设施

• 批准号: 7615050
• 负责人: GARY Lee FRANCIS
• 金额: $ 24.1万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7615050
• 关键词: Administrator; Biochemistry; Blood; Blood Platelets; Classification; Clinic; Clinical; Clinical Data; Clinical Research; Computers; Coronary Arteriosclerosis; DNA analysis; Data; Databases; Family; Family Physicians; Functional disorder; Genes; Genetic; Goals; Human Resources; Leadership; Link; Longitudinal Studies; Molecular Genetics; Nursing Research; Patients; Physicians; Recruitment Activity; Research; Research Ethics Committees; Research Infrastructure; Resistance; Sampling; Scientist; Site; Thrombosis; Time; clinical phenotype; design; experience; follow-up; improved

The Clinical Infrastructure Core is an indispensable component of the SCCOR proposal. It is the unifying link that serves each Project in a very specific manner by providing blood for DNA analysis and assorted biochemistry determinations. Just as importantly, the Clinical Infrastructure Core collects, collates, files and retrieves all clinical data, thereby matching each scientific analysis to key clinical information. Moreover, the Clinical Infrastructure Core is responsible for recruiting patients, controls, and unique families for longitudinal study. It is also responsible for the systematic follow-up of these patients and their families. In reality, this is an enormous task, requiring the multiple interactions with patients, families, physicians, research nurses, scientists, IRBs and administrators. Hundreds of samples will be acquired, stored, retrieved and analyzed. An exceptionally large database of clinical, demographic, angiographic, electrocardiographic and echocardiographic material will be generated and maintained. The group at the Cleveland Clinic has already assembled such an organization on site in the form of GeneBank, GeneQuest, CHARISMA and carotid stenting. We have now several years of experience with these two large and important data repositories, generously maintained by strong institutional support. We have space and a large cadre of research nurses, computers, technicians and some physicians to operate this labor-intensive infrastructure. Over time, its operational aspects have improved, and important new data on genes and coronary artery disease are currently emerging. We now have an opportunity with the SCCOR to expand our research goals and further link our clinical phenotype information in the data banks to the genetic and molecular pathophysiology of coronary artery disease. The Clinical Infrastructure Core is clearly essential to this end. We believe that under the able leadership of Drs. Gary Francis and our many dedicated personnel, that we can leverage our unique experience with GeneBank and GeneQuest to focus on new and tightly integrated SCCOR projects designed to explore and better understand the genetics of thrombosis and resistance to anti-platelet agents.

临床基础设施核心是SCCOR提案不可或缺的组成部分。它是统一的纽带 它以非常具体的方式为每个项目服务，为DNA分析提供血液， 生物化学测定同样重要的是，临床基础设施核心收集、整理、归档和 检索所有临床数据，从而将每个科学分析与关键临床信息相匹配。而且 临床基础设施核心负责招募患者、对照和独特家族， study.它还负责对这些病人及其家属进行系统的跟踪。实际上，这是一个 巨大的任务，需要与患者，家属，医生，研究护士，科学家， IRB和管理员。将采集、储存、检索和分析数百个样本。一个 临床、人口统计学、血管造影、心电图和超声心动图的超大数据库 材料将被生成和保存。克利夫兰诊所的研究小组已经组装了这样一个 组织在现场的形式基因库，基因探索，魅力和颈动脉支架。我们现在已经 这两个大型而重要的数据存储库的多年经验，由 强大的机构支持。我们有空间和大量的研究护士，计算机，技术人员和 一些医生来操作这个劳动密集型的基础设施。随着时间的推移，其业务方面有所改善， 关于基因和冠状动脉疾病的重要新数据正在出现。我们现在有一个 机会与SCCOR扩大我们的研究目标，并进一步联系我们的临床表型信息， 冠状动脉疾病的遗传和分子病理生理学的数据库。临床 基础设施核心显然对实现这一目标至关重要。我们相信在加里博士的领导下 弗朗西斯和我们的许多敬业的工作人员，我们可以利用我们与基因库的独特经验， GeneQuest将专注于新的紧密集成的SCCOR项目，旨在探索和更好地了解 血栓形成和抗血小板药物耐药性的遗传学。