Neural Circuits underlying Innate Odor Preference in Drosophila
果蝇先天气味偏好的神经回路
基本信息
- 批准号:7774557
- 负责人:
- 金额:$ 18.65万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-30 至 2011-08-31
- 项目状态:已结题
- 来源:
- 关键词:Animal ModelAnimalsBasic ScienceBehaviorBehavioralBehavioral AssayBehavioral ParadigmBiological AssayBrainCalciumCuesDataDecision MakingDissectionDrosophila genusDrug AddictionElementsEnvironmentEsthesiaFutureGeneticGoalsImaging TechniquesImaging technologyInstinctLabelLinkLobeMapsMediatingMicroscopyMolecular GeneticsMushroom BodiesNatureNeuronsOdorant ReceptorsOdorsOrganismOutputPatternPerceptionPeripheralPlayPopulationProcessResearchResolutionRewardsRoleSensorySensory ProcessShapesSignal TransductionSmell PerceptionStimulusSystemTherapeutic InterventionVinegarWorkcognitive functionflygenetic manipulationhedonicknowledge basemotivated behaviorneural circuitneurogeneticsolfactory stimulusoptical imagingpreferencepublic health relevancereceptorrelating to nervous systemresearch studyresponsesensory stimulussensory systemtwo-photon
项目摘要
DESCRIPTION (provided by applicant): Information about the external world arrives at our brain via sensory system. Sensory stimuli interact with receptor neurons in the periphery to generate sensation. Interpretation of the peripheral neural activity by the central circuitry leads to perception of the external world. What features of an animal's sensory world are relevant to behavior? How are the important sensory cues processed in the central brain to generate appropriate behavioral output? This proposal focuses on studying the neural representation of innately attractive and aversive odorants at the level of both primary and secondary sensory processing centers in an effort to uncover hard wired neural circuits that encode negative or positive valence in a simple model organism. The proposed experiments will be carried out in Drosophila, an organism with an anatomically simple olfactory system that is amenable to molecular and genetic manipulations, optical imaging technologies, and behavioral analysis. The experiments outlined here investigate the hypothesis that innately attractive and aversive odorants are encoded by separate labeled-line circuits. The goals of these experiments are: 1) to define key circuit elements at the level of the antennal lobe, a primary sensory processing center for olfaction, that mediate attraction or aversion to olfactory stimuli; 2) to examine the representation of attractive and aversive odorants at higher brain center such as the mushroom body. These findings would then serve as a platform for launching a longer-term project directed at olfactory perception and decision- making at higher brain centers, where valence is assigned to stimuli encountered in the environment for appropriate motivated behaviors.
PUBLIC HEALTH RELEVANCE: Drug addiction through neural circuit of reward signal has a profound impact on sensory perception. The work of this proposal is basic science that seeks to reveal the neural circuit underlying olfactory perception, creating a knowledge base from which potential neuron population can be evaluated for future therapeutic interventions of drug addiction.
描述(由申请人提供):关于外部世界的信息通过感觉系统到达我们的大脑。感觉刺激与外周的受体神经元相互作用以产生感觉。中央回路对周围神经活动的解释导致对外部世界的感知。动物感觉世界的哪些特征与行为相关?重要的感觉线索在中枢大脑中是如何处理的,以产生适当的行为输出?该建议的重点是在初级和次级感觉处理中心的水平上研究先天吸引和厌恶气味的神经表征,以揭示简单模型生物中编码负或正价的硬连线神经回路。拟议的实验将在果蝇中进行,果蝇是一种具有解剖学上简单的嗅觉系统的生物体,可以进行分子和遗传操作,光学成像技术和行为分析。这里概述的实验调查的假设,天生的吸引力和厌恶的气味是由单独的标记线电路编码。这些实验的目的是:1)在触角叶(嗅觉的主要感觉处理中心)水平上定义关键回路元件,介导对嗅觉刺激的吸引或厌恶; 2)检查吸引和厌恶气味在高级大脑中心(如蘑菇体)的表征。然后,这些发现将作为一个平台,用于启动一个针对高级大脑中心嗅觉感知和决策的长期项目,在高级大脑中心,效价被分配给环境中遇到的刺激,以产生适当的动机行为。
公共卫生相关性:药物成瘾通过奖赏信号的神经回路对感官知觉产生深远影响。这项提案的工作是基础科学,旨在揭示嗅觉感知背后的神经回路,创建一个知识库,从中可以评估潜在的神经元群体,用于未来的药物成瘾治疗干预。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jing W Wang其他文献
Jing W Wang的其他文献
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{{ truncateString('Jing W Wang', 18)}}的其他基金
Engineering an activity-dependent transcription factor for mapping neural circuits
设计一种活动依赖性转录因子来绘制神经回路
- 批准号:
9022518 - 财政年份:2015
- 资助金额:
$ 18.65万 - 项目类别:
Drosophila: Metabolic Modulation of Olfactory Circuit Function/ Feeding Behavior
果蝇:嗅觉回路功能/进食行为的代谢调节
- 批准号:
8865608 - 财政年份:2011
- 资助金额:
$ 18.65万 - 项目类别:
Drosophila: Metabolic modulation of olfactory circuit function/ feeding behavior
果蝇:嗅觉回路功能/进食行为的代谢调节
- 批准号:
8690838 - 财政年份:2011
- 资助金额:
$ 18.65万 - 项目类别:
Drosophila: Metabolic modulation of olfactory circuit function/ feeding behavior
果蝇:嗅觉回路功能/进食行为的代谢调节
- 批准号:
8306793 - 财政年份:2011
- 资助金额:
$ 18.65万 - 项目类别:
Drosophila: Metabolic modulation of olfactory circuit function/ feeding behavior
果蝇:嗅觉回路功能/进食行为的代谢调节
- 批准号:
8494044 - 财政年份:2011
- 资助金额:
$ 18.65万 - 项目类别:
Drosophila: Metabolic modulation of olfactory circuit function/ feeding behavior
果蝇:嗅觉回路功能/进食行为的代谢调节
- 批准号:
8161956 - 财政年份:2011
- 资助金额:
$ 18.65万 - 项目类别:
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