OHTS--KRESGE EYE INSTITUTE

描述（研究者摘要） 这是申请成为参与临床中心的申请， 高眼压治疗研究（OHTS）。 完整的细节 OHTS原理、设计和方法包含在OHTS手册中， 程序. 本提案提供了完整的文档， 的Kresge眼科研究所筛查大量高眼压患者， 患者，并在24个月内入组至少50例合格患者 期 提供了有关拟议的 研究者及其工作人员根据雅阁开展研究 OHTS程序手册的细节， 他们对Kresge眼科研究所的承诺，以及5名眼科医生的名单 在该地区谁将转介或跟踪筛选入组的患者， 在OHTS临床试验中随机分配至治疗。 主要研究者是一名受过培训且经验丰富的研究员 青光眼专科医生积极参与青光眼转诊实践， Kresge眼科研究所，拟议的临床中心，这是一个 卓越的临床中心和一个主要的眼科研究中心， 底特律医疗中心和韦恩医院眼科 州立大学医学院 拥有430万人口的大都会。 主要研究者执行 每年约10，000例患者检查，约500例切口青光眼 外科手术，以及大约700例青光眼激光外科手术。 首席研究员、他的临床研究员和住院医师也治疗 超过5，000名青光眼或高眼压患者在 Kresge眼科研究所居民青光眼诊所和退伍军人 医院眼科门诊部 此外，校长 研究者已经从其患者人群中确定了75例眼部 作为资格考试候选人的高血压患者 根据研究的合格性和排除标准确定OHTS。 因此，对于主要研究者来说， Kresge眼科研究所招募至少50名合格的眼 高血压性青光眼嫌疑人，如果有必要，更多，特别是与 5名合作者、其他社区眼科医生的帮助， 采用有效的招聘方法。

DESCRIPTION (Investigator's Abstract) This is an application to become a participating Clinical Center in the Ocular Hypertension Treatment Study (OHTS). The complete details of the OHTS rationale, design, and methods are contained in the OHTS Manual of Procedures. This proposal provides complete documentation of the ability of Kresge Eye Institute to screen large numbers of ocular hypertensive patients and to enroll at least 50 eligible patients over a 24-month period. Documentation is provided of the capabilities of the proposed investigator and his staff for the performance of the Study in accord with the details of the OHTS Manual of Procedures, the nature and extent of their commitment to Kresge Eye Institute, and a list of 5 ophthalmologists in the area who will refer or follow patients screened for enrollment and randomization to treatment in the OHTS clinical trial. The Principal Investigator is a fellowship trained and experienced glaucoma subspecialist actively engaged in a referral glaucoma practice at the Kresge Eye Institute, the proposed clinical center, which is a clinical center of excellence and a major eye research center as the Department of Ophthalmology for the Detroit Medical Center and the Wayne State University School of Medicine in the greater Detroit urban metropolis of 4.3 million people. The Principal Investigator performs annually about 10,000 patient examinations, about 500 incisional glaucoma surgical procedures, and about 700 glaucoma laser surgical procedures. The Principal Investigator, his clinical fellows, and residents also treat more than 5,000 patients with glaucoma or ocular hypertension at the Kresge Eye Institute residents' glaucoma clinic and the Veterans Administration Hospital Eye Clinic. In addition, the Principal Investigator has already identified from his patient population 75 ocular hypertensive patients who are candidates for the qualifying examinations of the OHTS based on the Study's eligibility and exclusion criteria. Therefore, it will be readily feasible for the Principal Investigator of the Kresge Eye Institute to enroll at least 50 eligible ocular hypertensive glaucoma suspects and if necessary many more especially with the help of the 5 collaborators, other community ophthalmologists, and with the use of effective recruitment methods.