Eastern Cooperative Oncology Group

描述（由申请人提供）：本拨款的主要目的是确保资金支持范德比尔特大学医学中心东部肿瘤合作小组（ECOG）的临床研究活动，促进ECOG试验的患者累积，并扩大范德比尔特大学研究人员对ECOG的科学和行政贡献。该建议的具体目标是：1)增加对ECOG赞助的临床试验的参与，2)进一步增加Vanderbilt研究者对ECOG的科学和管理贡献，3)继续开发常见实体瘤和血液恶性肿瘤的创新治疗方案，4)为与ECOG试验相关的相关实验室项目提供基础科学专业知识，5)保持高水平的数据质量和管理，这是该机构闻名的。这些目标将通过来自医学肿瘤学、放射肿瘤学、病理学和外科科学部门的研究人员的密切互动来实现。范德比尔特大学的研究人员在ECOG疾病导向和模式委员会的存在将促进范德比尔特大学和其他ECOG机构之间的互动。范德比尔特-英格拉姆综合癌症中心拥有成功执行合作小组临床试验的所有必要因素，包括优秀的数据管理人员，出色的门诊和住院设施，这项工作将在其中进行，以及合作小组参与的悠久历史。

DESCRIPTION (provided by applicant): The principal objectives of this grant are to secure funding to support the clinical research activity of the Eastern Cooperative Oncology Group (ECOG) at Vanderbilt University Medical Center, to facilitate patient accrual to ECOG trials, and to expand the scientific and administrative contributions made to ECOG by Vanderbilt investigators. The specific aims of the proposal are: 1) to increase participation in ECOG sponsored clinical trials, 2) to further increase the scientific and administrative contributions to ECOG by Vanderbilt investigators, 3) to continue the development of innovative treatment programs for common solid tumors and hematologic malignancies, 4) to provide basic science expertise for correlative laboratory projects attached to ECOG trials and 5) to maintain a high level of data quality and management for which this institution is known. These goals will be achieved through the close interaction of investigators from medical oncology, radiation oncology, pathology and the section of surgical sciences. The interactions between Vanderbilt and other ECOG institutions will be facilitated by the presence of Vanderbilt investigators on ECOG disease oriented and modality committees. The Vanderbilt-lngram Comprehensive Cancer Center has in place all the necessary elements for the successful execution of cooperative group clinical trials including an outstanding data management staff, excellent outpatient and inpatient facilities in which this work will be undertaken and a long history of cooperative group participation.