DNA repair dysfunction in neurodegeneration

神经退行性疾病中的 DNA 修复功能障碍

• 批准号: 7732296
• 负责人: Vilhelm Bohr
• 金额: $ 30.99万
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7732296
• 关键词: Age; Aging; Biological Assay; Brain; Cellular Assay; Condition; DNA; DNA Damage; DNA Repair; Functional disorder; Human; Individual; Mus; Nerve Degeneration; Neurons; Neurotransmitters; Oxidative Stress; Rattus; Synapses; UV induced DNA damage; attenuation; mouse model; neurotransmission; novel; oxidative DNA damage; repaired; theories

We have studied DNA repair in individual primary rat neurons. The neurons repair many kinds of DNA damage, and it is particularly novel that they repair UV induced DNA damage. We find attenuation of oxidative DNA damage repair in differentiating neurons and we find that the DNA repair in the synaptic region is quite robust after oxidative stress. Furthermore, there seems to be a connection between neurotransmission and DNA repair because the addition of neurotransmitters to neurons incraeses the DNA damage and repair

我们研究了单个原代大鼠神经元的DNA修复。神经元可以修复多种DNA损伤，尤其是修复紫外线引起的DNA损伤。我们发现，在分化的神经元中，DNA氧化损伤修复能力减弱，我们发现，在氧化应激后，突触区域的DNA修复相当强劲。此外，神经传递和dna修复之间似乎有联系，因为神经递质的增加增加了dna的损伤和修复。