Hypervigilance versus perceptual avoidance in social phobia

社交恐惧症中的过度警惕与知觉回避

• 批准号: 7741500
• 负责人: Andreas Keil
• 金额: $ 23.87万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7741500
• 关键词: Address; Anxiety; Anxiety Disorders; Attention; Behavioral; Brain; Chronic; Cognitive; Cues; Data; Diagnosis; Diagnostic; Diagnostic Specificity; Disease; Elements; Emotional; Etiology; Event; Evidence based intervention; Exposure to; Eye Movements; Fright; Functional disorder; Galvanic Skin Response; Goals; Hand; Heart Rate; Individual; Intervention; Laboratories; Maintenance; Measures; Mental Health; Methodology; Methods; Nature; Outcome; Participant; Patient Self-Report; Patients; Pattern; Perception; Peripheral; Pharmaceutical Preparations; Physiological; Predictive Value; Process; Psychopathology; Psychophysiology; Reflex action; Reporting; Research; Resistance; Resource Allocation; Resources; Role; Sampling; Selection for Treatments; Selective Serotonin Reuptake Inhibitor; Severities; Social Phobia; Specific Phobia; Stimulus; Symptoms; Testing; Therapeutic; Time; Training; Treatment outcome; Visual; Visual evoked cortical potential; Work; base; clinical anxiety; cognitive behavior therapy; depression; improved; indexing; neurobehavioral; neuroimaging; neurophysiology; outcome forecast; panic disorder with agoraphobia; prognostic; prognostic indicator; public health relevance; response; selective attention; social; success; therapy outcome; vigilance; visual stimulus

DESCRIPTION (provided by applicant): Social phobia has been related to dysfunctions of attention allocation that include hyper-vigilance and subsequent perceptual avoidance of social threat cues. This hypothesized deficit has been difficult to test using behavioral and/or neurophysiological measures because continuous, near real-time measures of resource deployment were not available so far, and the covert processes of attention orienting can not be measured by means of behavioral approaches. The research proposed here directly addresses this difficulty, examining the time course of attentional resource allocation by means of steady-state visual evoked potentials (ssVEPs), evoked by flickering visual stimuli. This electroencephalographic (EEG) measure uniquely provides for a near real-time assessment of visual selective attention. The overall goal of the proposed research is to identify the role of dysfunctional attention to social threat cues in the psychopathology of social phobia. It is planned to determine whether individuals characterized by high social fear or by social phobia direct perceptual and attentional resources towards or away from social threat stimuli, and in what temporal order they do so. Combining the ssVEP approach with self-report, behavioral, and physiological measures, we first aim to quantify the relationship between attention dynamics and the intensity of then aim to study the relationship between dysfunctional attention dynamics and the severity of social phobia during social threat cue processing. Finally, we plan to assess the predictive value of ssVEP-based attention dynamics as prognostic assessment attention. This information has strong implications for improving treatment selection and outcome prognosis. Specifically, matching patients to exposure-based or cognitive treatments will benefit from information as to the nature of their hypervigilance vis-¿-vis avoidance of social threat cues. PUBLIC HEALTH RELEVANCE: Social phobia has been related to dysfunctions of attention allocation that may include chronic hyper-vigilance and subsequent perceptual avoidance of social threat cues. The research proposed here directly addresses the neurobehavioral mechanisms of such a deficit. It examines the time course of attentional resource allocation in relation to symptom severity of social phobia, and as a predictor of treatment outcome. This information has implications for improving treatment selection and outcome prognosis. Specifically, matching patients to exposure-based or cognitive treatments will benefit from information as to the nature of their hypervigilance vis-¿-vis avoidance of social threat cues.

描述（由申请人提供）：社交恐惧症与注意力分配功能障碍有关，包括过度警惕和随后对社交威胁线索的感知回避。这种假设的缺陷已经很难测试使用行为和/或神经生理学的措施，因为连续的，近实时的措施，资源部署是迄今为止，和注意定向的内隐过程不能通过行为的方法来测量。这里提出的研究直接解决这个困难，检查注意力资源分配的时间过程中的稳态视觉诱发电位（ssVEPs），诱发闪烁的视觉刺激。这种脑电图（EEG）测量独特地提供了视觉选择性注意力的近实时评估。这项研究的总体目标是确定对社会威胁线索的功能失调性注意在社交恐惧症的精神病理学中的作用。它计划确定是否具有高的社会恐惧或社会恐怖症的个人直接知觉和注意力资源朝向或远离社会威胁刺激，以及在什么时间顺序，他们这样做。将ssVEP方法与自我报告，行为和生理测量相结合，我们的目标首先是量化注意力动态和强度之间的关系，然后旨在研究在社会威胁线索处理过程中，功能失调的注意力动态和社交恐惧症的严重程度之间的关系。最后，我们计划评估ssVEP为基础的注意力动态的预测价值作为预后评估的注意力。这一信息对改善治疗选择和预后具有重要意义。具体来说，将患者与基于确认或认知的治疗相匹配，将受益于关于他们过度警惕维斯避免社会威胁线索的性质的信息。公共卫生关系：社交恐惧症与注意力分配功能障碍有关，可能包括慢性过度警惕和随后对社交威胁线索的感知回避。这里提出的研究直接解决了这种缺陷的神经行为机制。它检查了注意力资源分配的时间过程与社交恐惧症症状严重程度的关系，并作为治疗结果的预测因子。这一信息对改善治疗选择和预后有重要意义。具体来说，将患者与基于确认或认知的治疗相匹配，将受益于关于他们过度警惕维斯避免社会威胁线索的性质的信息。