CD137 SIGNALS IN DC DURING AG-PRIMING INDUCES TOLERANCE

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In the previous reporting period we confirmed that anti-CD137-mediated suppression could be induced in CD8 T cells, as well as CD4 T. Using P14 TCR transgenic T cells and CD137-deficient mice and we had found that the induction of suppression caused by anti-CD137 was independent of CD137 expression on T cells, and that the targeted cell type might be a subset of dendritic cells. In this reporting period we revisited the question of how anti-CD137 mAb signaling induced suppression of both CD4 and CD8 T cells during an acute LCMV Armstrong infection and in an acute influenza infection.