AMYGDALA VS HIPPOCAMPAL BDNF FUNCTION WITH MOLECULAR GENETIC TECHNIQUES

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During the reporting period, we combined a novel lentivirus vector that expresses the Cre recombinase with transgenic mice in which the BDNF gene has been flanked by LoxP sites (Floxed). We found that hippocampal bdnf and trkB activation within the amygdala are required for the normal extinction of fear. Additionally, we found that knocking out bdnf, specifically within the hippocampus, prevents extinction of fear.