AMYGDALA VS HIPPOCAMPAL BDNF FUNCTION WITH MOLECULAR GENETIC TECHNIQUES

杏仁核与海马 BDNF 功能与分子遗传技术

• 批准号: 7715761
• 负责人: KERRY J. RESSLER
• 金额: $ 2.85万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715761
• 关键词: Amygdaloid structure; BDNF gene; Computer Retrieval of Information on Scientific Projects Database; Extinction (Psychology); Fright; Funding; Genetic Techniques; Grant; Hippocampus (Brain); Institution; Knock-out; Lentivirus Vector; Molecular Genetics; Reporting; Research; Research Personnel; Resources; Site; Source; Transgenic Mice; United States National Institutes of Health; novel; prevent; recombinase

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During the reporting period, we combined a novel lentivirus vector that expresses the Cre recombinase with transgenic mice in which the BDNF gene has been flanked by LoxP sites (Floxed). We found that hippocampal bdnf and trkB activation within the amygdala are required for the normal extinction of fear. Additionally, we found that knocking out bdnf, specifically within the hippocampus, prevents extinction of fear.

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