The Effect of Postoperative Analgesics on Sleep of Rats

术后镇痛药对大鼠睡眠的影响

• 批准号: 7556340
• 负责人: SHARON L KOZACHIK
• 金额: $ 2.53万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-16 至 2009-06-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7556340
• 关键词: Acute; Acute Pain; Address; Adverse effects; Affect; Analgesics; Animals; Anti-Inflammatory Agents; Anti-inflammatory; Area; Attenuated; Complex; Data; Development; Electroencephalogram; Female; Filament; Hand; Health; Hour; Human; Implant; Inflammatory; Institute of Medicine (U.S.); Learning; Maintenance; Mechanics; Memory; National Institute of Nursing Research; Nature; Neuritis; Operative Surgical Procedures; Opiates; Opioid; Outcome; Pain; Pain management; Patients; Perception; Persistent pain; Persons; Pharmaceutical Preparations; Phase; Postoperative Pain; Postoperative Period; Public Health; Quality of Care; REM Sleep; Rattus; Recovery; Relative (related person); Reporting; Research; Research Institute; Risk; Sex Characteristics; Sleep; Sleep Architecture; Sleep Stages; Sleep disturbances; Sprague-Dawley Rats; Staging; Testing; Time; Translational Research; Treatment Protocols; United States National Institutes of Health; chronic pain; evidence base; experience; functional outcomes; improved; interest; male; non rapid eye movement; non-drug; restoration; sleep onset

DESCRIPTION (provided by applicant): Pain and sleep disturbance are significant public health problems. Postoperative pain and sleep disturbance are inter-related sequelae that can adversely affect recovery if not effectively managed. Several studies have shown that the degree of postoperative pain and acute sleep disruption predict adverse health and functional outcomes, including the development of persistent pain. Postoperative opioids, while effective in attenuating pain, may exert adverse effects on sleep. Non-steroidal anti-inflammatory drugs (NSAIDs) may not provide adequate pain relief when administered as stand-alone analgesic following more invasive surgeries; however, data suggest that their adverse effects on sleep may be minimal. To-date, research has not directly compared the effects of opioid versus NSAID, alone or in combination, on acute sleep changes, time to return to baseline sleep, or subsequent pain perception. A reasonable speculation is that patients who are administered opioid plus NSAID will experience better acute pain management, fewer adverse effects on their sleep, more rapid return to baseline sleep, and lower levels of subsequent pain. The purposes of this translational research are to explore in rats who receive a postoperative analgesic regimen of opioid or NSAID or both, whether there are differences in sleep architecture, sleep continuity, time to return to baseline sleep, or mechanical sensitivity, relative to the postoperative analgesic regimen, and whether there are sex differences in these outcomes. Male and female Sprague Dawley rats who are 14-16 weeks old will be implanted with telemetric transmitters to record electroencephalogram/electromyogram biopotentials for baseline and postoperative sleep, and following recovery, will undergo the Sciatic Inflammatory Neuritis (SIN) surgery and then receive one of three postoperative analgesic regimens: 1) opioid, 2) NSAID, or 3) opioid plus NSAID. Following recovery, animals will be tested for mechanical sensitivity using von Frey filaments. This proposed research addresses areas of needed research as identified by the National Institutes of Health, the National Institute of Nursing Research, and the Institute of Medicine. Through exploring whether particular postoperative analgesic regimens are less disruptive of sleep, this proposed research has the potential to improve the quality of care to persons currently taking prescribed analgesics for pain.

描述（由申请人提供）：疼痛和睡眠障碍是重要的公共卫生问题。术后疼痛和睡眠障碍是相互关联的后遗症，如果不能有效管理，可能会对恢复产生不利影响。几项研究表明，术后疼痛和急性睡眠中断的程度预示着不良的健康和功能结果，包括持续性疼痛的发展。术后阿片类药物虽然能有效减轻疼痛，但可能对睡眠产生不良影响。非甾体类抗炎药（NSAID）在侵入性手术后作为独立镇痛药给药时可能无法充分缓解疼痛;然而，数据表明其对睡眠的不良影响可能很小。迄今为止，研究尚未直接比较阿片类药物与NSAID单独或联合使用对急性睡眠变化、恢复基线睡眠时间或随后疼痛感知的影响。一个合理的推测是，给予阿片类药物加NSAID的患者将经历更好的急性疼痛管理，对睡眠的不良影响更少，更快地恢复到基线睡眠，随后的疼痛水平更低。本转化研究的目的是在接受阿片类药物或NSAID或两者的术后镇痛方案的大鼠中探索相对于术后镇痛方案，睡眠结构、睡眠连续性、恢复基线睡眠的时间或机械敏感性是否存在差异，以及这些结局是否存在性别差异。14-16周龄的雄性和雌性Sprague道利大鼠将植入遥测发射器以记录基线和术后睡眠的脑电图/肌电图生物电位，并且在恢复后，将经历坐骨炎性神经炎（SIN）手术，然后接受三种术后镇痛方案之一：1）阿片类药物，2）NSAID，或3）阿片类药物加NSAID。恢复后，将使用von Frey细丝测试动物的机械敏感性。这项拟议的研究涉及美国国立卫生研究院、美国国立护理研究所和医学研究所确定的需要研究的领域。通过探索特定的术后镇痛方案是否对睡眠的干扰较小，这项拟议的研究有可能提高目前服用处方镇痛药治疗疼痛的人的护理质量。

项目成果

Oncology nursing society putting evidence into practice resources: where are we now and what is next?

肿瘤护理学会将证据付诸实践资源：我们现在在哪里，下一步是什么？

• DOI: 10.1188/08.cjon.965-970
• 发表时间: 2008
• 期刊: Clinical journal of oncology nursing
• 影响因子: 1.1
• 作者: Doorenbos,ArdithZ;Berger,AnnM;Brohard-Holbert,Cheryl;Eaton,Linda;Kozachik,Sharon;LoBiondo-Wood,Geri;Mallory,Gail;Rue,Tessa;Varricchio,Claudette
• 通讯作者: Varricchio,Claudette

2008 ONS research priorities survey.

2008 年 ONS 研究重点调查。

• DOI: 10.1188/08.onf.e100-e107
• 发表时间: 2008
• 期刊: Oncology nursing forum
• 影响因子: 1.9
• 作者: Doorenbos,ArdithZ;Berger,AnnM;Brohard-Holbert,Cheryl;Eaton,Linda;Kozachik,Sharon;LoBiondo-Wood,Geri;Mallory,Gail;Rue,Tessa;Varricchio,Claudette
• 通讯作者: Varricchio,Claudette