WNPRC GENETICS SERVICES UNIT

WNPRC 遗传学服务单位

• 批准号: 7716455
• 负责人: David H. O'Connor
• 金额: $ 40.96万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-23 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716455
• 关键词: Acquired Immunodeficiency Syndrome; American; Biological Assay; Biomedical Research; Chinese People; Computer Retrieval of Information on Scientific Projects Database; Educational workshop; Family suidae; Funding; Genetic; Genetic Services; Genotype; Grant; Immunologist; Improve Access; Institution; Laboratories; Lead; Macaca; Macaca mulatta; Manuscripts; Methods; Microsatellite Repeats; Publications; Reporting; Research; Research Personnel; Resolution; Resource Allocation; Resources; Sampling; Services; Source; Sus scrofa; Tail; Training; Transplantation; United States National Institutes of Health; base; genetic pedigree; genetic resource; lectures; symposium

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To provide core, campus and non-host investigators with sophisticated and specialized genetics resources and expertise. Progress and concerns In 2007 Genetics Services focused on improving access to MHC genotyping in macaques. Microsatellite based haplotyping is now used for sample authentication, pedigree verification, and genotyping of Mauritian origin cynomolgus macaques. Specialized MHC genotyping services are also available for Chinese rhesus macaques, pig-tailed macaques, and cynomolgus macaques from various origins. Genetics Services is taking the lead in developing high-resolution, sensitive, and economical assays for complete MHC genotyping in macaques. Allocation of resource access The Genetics Service provided MHC genotyping support to more than 20 laboratories in 2007. Dissemination We request that projects utilizing Genetics Service acknowledge the service in manuscripts and presentations. Dr. O'Connor, the PI for Genetics Services, lectures regularly on NHP genetics. Training Methods for MHC genotyping are regularly discussed during scientific conferences attended by Dr. O'Connor and his staff. In 2007, this included presentations at the American Association of Immunologists conference, an NIH workshop on transplantation, and an NIH workshop on the use of NHP in biomedical research. Publications There were no new publications explicit to Genetics Services during this reporting period. We expect collaborative projects emanating from genotyping performed in 2007 during the next reporting period. Note: AIDS related

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 为核心、校园和非东道主研究人员提供复杂和专业的遗传学资源和专业知识。 进展和关切 2007年，遗传学服务的重点是改善猕猴MHC基因分型的可及性。基于微卫星的单倍体分析现在用于样本鉴定、系谱验证和毛里求斯食蟹猴的基因分型。专门的MHC基因分型服务也适用于来自不同来源的中国恒河猴、猪尾猕猴和食蟹猴。遗传学服务公司正在带头开发高分辨率、灵敏和经济的猕猴MHC基因分型方法。 资源访问权限的分配 2007年，遗传局为20多个实验室提供了MHC基因分型支持。 传播 我们要求利用遗传学服务的项目在手稿和演示文稿中承认这项服务。O‘Connor博士是遗传学服务的PI，定期讲授NHP遗传学。 培训 在奥康纳博士和他的工作人员参加的科学会议上，MHC基因分型的方法经常被讨论。2007年，这包括在美国免疫学家协会会议、NIH移植研讨会和NIH在生物医学研究中使用NHP的研讨会上的演讲。 出版物 在本报告所述期间，没有明确向Genetics Services发布的新出版物。我们预计，在下一个报告期内，将于2007年开展基因分型方面的合作项目。 注：与爱滋病有关