WNPRC GENETICS SERVICES UNIT

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To provide core, campus and non-host investigators with sophisticated and specialized genetics resources and expertise. Progress and concerns In 2007 Genetics Services focused on improving access to MHC genotyping in macaques. Microsatellite based haplotyping is now used for sample authentication, pedigree verification, and genotyping of Mauritian origin cynomolgus macaques. Specialized MHC genotyping services are also available for Chinese rhesus macaques, pig-tailed macaques, and cynomolgus macaques from various origins. Genetics Services is taking the lead in developing high-resolution, sensitive, and economical assays for complete MHC genotyping in macaques. Allocation of resource access The Genetics Service provided MHC genotyping support to more than 20 laboratories in 2007. Dissemination We request that projects utilizing Genetics Service acknowledge the service in manuscripts and presentations. Dr. O'Connor, the PI for Genetics Services, lectures regularly on NHP genetics. Training Methods for MHC genotyping are regularly discussed during scientific conferences attended by Dr. O'Connor and his staff. In 2007, this included presentations at the American Association of Immunologists conference, an NIH workshop on transplantation, and an NIH workshop on the use of NHP in biomedical research. Publications There were no new publications explicit to Genetics Services during this reporting period. We expect collaborative projects emanating from genotyping performed in 2007 during the next reporting period. Note: AIDS related