Administrative Core

行政核心

• 批准号: 10220699
• 负责人: David H. O'Connor
• 金额: $ 27.5万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10220699
• 关键词: Administrator; Americas; Animals; Arbitration; Biological; Charge; Collaborations; Communication; Communication Tools; Communities; Complex; Dangerousness; Development; Disputes; Doctor of Philosophy; Ensure; Equipment and supply inventories; Experimental Designs; Fetus; Functional disorder; Goals; Health Personnel; Human Resources; Infection; Institution; International; Intranet; Lead; Leadership; Natural Immunity; Participant; Policies; Pregnancy; Pregnant Women; Progress Reports; Protocols documentation; Reporting; Research; Research Personnel; Risk; Sampling; Scientist; Shipping; Students; System; Time; Training; United States National Institutes of Health; Vaccination; Vertebrates; Viremia; Work; ZIKA; Zika Virus; conflict resolution; congenital zika syndrome; data sharing; experience; meetings; member; neonate; programs; tool

Admin Core - Project Summary/Abstract The rapid and explosive spread of Zika virus has lead to the recognition that infection during pregnancy can lead to congenital Zika syndrome. The key hypothesis of this Program Project is that prolonged maternal viremia during pregnancy predicts the risk of congenital Zika syndrome. We will explore this hypothesis through three integrated projects. The Administrative (Admin) Core is charged with coordi- nating activities of the entire Program Project to ensure timely and efficient completion of the overall scientific goals. The activities of the Admin Core are broadly divided into five Specific Aims: Specific Aim 1. Coordinating communications between all participants. Specific Aim 2. Ensuring and maintaining regulatory compliance. Specific Aim 3. Managing program finances and overseeing subawards. Specific Aim 4. Enforcing policies pertaining to scientific rigor, transparency, data sharing, and con- flict resolution. Specific Aim 5. Promoting professional development of students and junior scientists participating in this Program Project. ZIKV is dangerous to pregnant women and their fetuses/neonates throughout the Americas. This risk will persist for at least several years, even if it is eventually curtailed by natural immunity and widespread vaccination. The Admin Core will coordinate all the Projects to ensure completion of all the scientific goals, providing important new tools for pregnant women and their healthcare providers to assess, and potentially reduce, the risk of congenital Zika syndrome.

管理核心-项目摘要/摘要