PHARMACOLOGY STUDY IN COMMON MARMOSETS

普通狨猴的药理学研究

• 批准号: 7715534
• 负责人: JOAN H LANE
• 金额: $ 5.52万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-05 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715534
• 关键词: Acquired Immunodeficiency Syndrome; Body Composition; Cachexia; Callithrix jacchus jacchus; Clinical; Computer Retrieval of Information on Scientific Projects Database; Condition; Development; Disease; Elderly; Fracture; Funding; Grant; Incidence; Institution; Invasive; Lead; Magnetic Resonance Imaging; Malignant Neoplasms; Modeling; Muscle; Pharmacology; Research; Research Personnel; Resources; Source; Testing; Therapeutic; United States National Institutes of Health; age related; design; falls; in vivo; outcome forecast; sarcopenia; wasting

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Loss of muscle mass (cachexia) is associated with a variety of diseases including cancer and AIDS and is associated with a poor disease prognosis. Additionally, age related muscle loss (sarcopenia) can lead to decreased mobility and increased incidence of falls and fractures in the elderly. The current study was designed to test the efficacy of a proprietary compound to increase muscle mass. The study includes the use of non invasive in vivo MRI (EchoMRI) analysis to identify changes in body composition associated with compound administration. The results of this study will aid in the development of a clinical therapeutic model for treatment of muscle wasting conditions.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 肌肉质量的丧失（Cachexia）与包括癌症和艾滋病在内的多种疾病有关，并且与疾病预后不良有关。 此外，与年龄相关的肌肉损失（肌肉减少症）会导致老年人的迁移性降低和跌倒和骨折的发病率增加。当前的研究旨在测试专有化合物增加肌肉质量的功效。 该研究包括使用非侵入性体内MRI（ECHOMRI）分析来识别与化合物给药相关的身体成分的变化。 这项研究的结果将有助于开发用于治疗肌肉浪费条件的临床治疗模型。