IMMUNOGENICITY OF HIV CANDIDATE VACCINES IN BABOONS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 人类免疫缺陷病毒（HIV）在21年前被确定为艾滋病的病原体，该病毒已造成约2300万人死亡，估计全世界已感染近4600万人。 没有有效的疫苗可预防病毒的进一步传播。 在这个提议中，我们将在狒狒模型中研究新的候选艾滋病疫苗的免疫原性，希望能确定一个合适的疫苗配方进行人体试验。拟议项目共需要60只狒狒。 每组8 - 12只狒狒将用于检测不同候选疫苗的免疫原性。 我们计划每隔6 - 8个月使用8 - 12只狒狒检测每种候选疫苗的免疫原性。 因此，检测的候选疫苗总数将在5-7个范围内。 整个提案的实验目的是评价不同候选疫苗的相对免疫原性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Human immunodeficiency virus (HIV) was identified as the causative agent of AIDS more then 21 years ago and the virus has killed approximately 23 million people and is estimated to have infected nearly 46 million people worldwide. No effective vaccine is available for prevention of further spread of the virus. In this proposal, we will examine the immunogenicity of novel candidate AIDS vaccines in the baboon model to hopefully identify a suitable vaccine formulation for human trials. A total of 60 baboons are requested for the proposed project. Groups of 8 to 12 baboons will be used for testing the immunogenicity of different candidate vaccines. We plan to use 8 to 12 baboons for testing the immunogenicity of each candidate vaccine at 6 to 8 month intervals. Therefore, the total number of vaccine candidates tested will range from 5-7. The experimental objective for the entire proposal is to evaluate the relative immunogenicity of different vaccine candidates.