BABOON AS A MODEL FOR PROSTATE SERUM ANTIGEN BIOLOGY STUDIES

狒狒作为前列腺血清抗原生物学研究的模型

• 批准号: 7716134
• 负责人: James Nkambwe Mubiru
• 金额: $ 0.01万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716134
• 关键词: Accounting; Affect; Age; Animal Model; Animals; Antigens; Biology; Blood; Blood specimen; Body fat; Cessation of life; Clinical; Computer Retrieval of Information on Scientific Projects Database; Data; Diagnostic; Disease; Funding; Genetic; Grant; Human; Individual; Institution; Learning; Life; Malignant Neoplasms; Malignant neoplasm of prostate; Measures; Modeling; Obesity; PSA level; PSA screening; Papio; Physiological; Pilot Projects; Prostate; Prostate-Specific Antigen; Public Health; Purpose; Research; Research Personnel; Resources; Screening procedure; Series; Serum; Source; Testing; United States National Institutes of Health; Variant; male; men; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Prostate cancer is a major public health problem, accounting for more than 230,000 cases and more than 30,000 deaths per year in the US. The best tool for detecting prostate cancer early, and therefore beginning treatment before the disease progresses significantly, is the common prostate specific antigen or PSA test. This test uses a simple blood sample to measure the amount of PSA circulating. High levels of PSA indicate possible cancer. More than 45 million PSA tests are done worldwide each year because this is an effective diagnostic and screening tool that has saved many lives. However, there are still problems with the PSA test. Most importantly, about 25% of men with elevated PSA levels do not have cancer, and about one quarter of men with prostate cancer do not have high PSA levels, and are therefore not detected by the current PSA test. Clinicians have been forced to conclude that although blood PSA testing is a valuable and important tool, we still need to learn more about the causes of individual variation in PSA levels. The data show that cancer is one reason for high PSA levels, but there must be other reasons as well. In addition, there must be some reason why some men with cancer do not show high levels. The best hypotheses to explain the variation in PSA levels that is not due to cancer are: A) genetic differences among men influence their PSA levels, separate from cancer, and B) obesity and physiological changes related to obesity also affect PSA levels. The purpose of this pilot study is to investigate baboons as a new animal model to study the causes of individual variation in PSA levels. Baboons are an excellent choice for this because they do not get prostate cancer. As a result, we can study differences in PSA levels without worrying that some animals may have higher than average PSA levels due to early undiagnosed prostate cancer. We will conduct a series of analyses of PSA levels among 250 male baboons. These analyses will tell us whether: a) genetic differences among baboons influence PSA levels, b) age influences baboon PSA as it does human PSA, and c) differences in body fat and obesity among the baboons also influence PSA levels. The results of this pilot study will be important in developing larger research applications to the National Institutes of Health to study this important clinical problem that affects thousands of men in the US each year.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 前列腺癌是一个主要的公共卫生问题，在美国每年有超过23万例前列腺癌病例和超过3万例死亡。早期发现前列腺癌，从而在疾病显著进展之前开始治疗的最好工具是常见的前列腺特异性抗原或PSA测试。这项测试使用一个简单的血液样本来测量PSA循环的数量。PSA的高水平提示可能是癌症。全世界每年进行超过4500万次PSA检测，因为这是一种有效的诊断和筛查工具，拯救了许多人的生命。然而，PSA测试仍然存在问题。最重要的是，大约25%的PSA水平升高的男性没有患癌症，大约四分之一的前列腺癌男性没有高PSA水平，因此没有被目前的PSA测试检测到。 临床医生被迫得出结论，尽管血液PSA检测是一项有价值和重要的工具，但我们仍然需要更多地了解PSA水平个体差异的原因。数据显示，癌症是PSA水平高的一个原因，但肯定还有其他原因。此外，一定有一些患有癌症的男性没有表现出高水平的原因。解释PSA水平不是由癌症引起的变化的最佳假设是：A)男性之间的遗传差异影响他们的PSA水平，而不是癌症；B)肥胖和与肥胖有关的生理变化也影响PSA水平。 这项先导性研究的目的是将狒狒作为一种新的动物模型来研究PSA水平个体差异的原因。在这方面，狒狒是一个很好的选择，因为它们不会患前列腺癌。因此，我们可以研究PSA水平的差异，而不必担心一些动物的PSA水平可能会因为早期未诊断的前列腺癌而高于平均水平。我们将对250只雄性狒狒的PSA水平进行一系列分析。这些分析将告诉我们：a)狒狒之间的遗传差异是否会影响PSA水平，b)年龄是否会像影响人类PSA一样影响狒狒PSA，以及c)身体脂肪和肥胖程度的差异是否也会影响PSA水平。这项先导性研究的结果将对美国国立卫生研究院开发更大规模的研究应用程序具有重要意义，以研究这一每年影响美国数千名男性的重要临床问题。