NIEHS CENTER FOR HEALTH EFFECTS OF AGROCHEMICALS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：UCD的NIEHS环境健康科学中心的主要目标是在农用化学品和相关外来生物的毒理学方面保持强有力的计划，特别是与人类健康和毒理学的机制方面有关的毒理学。已经组建了一个由20名中心调查人员组成的团队，他们的兴趣与中心的目标特别一致。这些研究人员每年总共负责近1200万美元的研究经费(直接费用)。该中心的成员包括新的和有经验的科学家，许多感兴趣的领域，以及丰富的合作历史。为了建立促进小组内部和小组之间关系的基础设施，中心进行了重组，形成了七个设施/服务核心：(1)行政、(2)分析生物化学、(3)细胞/组织培养、(4)细胞和分子成像、(5)实地研究(6)功能基因组学和分子生物学以及(7)灵长类/动物模型。此外，为了促进有重点的研究工作、智力刺激和协同作用，已经形成了五个研究核心：(1)流行病学，(2)分子神经毒理学，(3)生殖和发育毒理学，(4)呼吸毒理学，以及我们的最新核心，(5)毒物基因组学。这些核心的组成发生了变化，为中心的研究方向提供了灵活性。试点项目计划用于引入新的调查人员和研究想法。开发了一个附属科学家类别，通过一个不像正式成员那样正式的机制来认可与UCD教职员工的互动，并任命了11名新的附属成员。新的CoEP得到了中心主任的精心指导，在新协调员丽贝卡·莫里森的领导下，Coep Mini-Grants计划是一个发现新想法的有效计划。从这些想法中产生了一个成功的长期计划，目前支持四个针对农业工人的外展计划，三个K-12计划，以及一个校友/公司外展计划。此外，在本项目期间，环境保护委员会举办了一次关于老龄化问题的全国研讨会和一次市政厅会议，并于1999年主办了关于生态系统健康的国际大会和2000年关于卤化环境有机污染物和持久性有机污染物的第二十次国际研讨会。COEP还充当公众的环境健康信息中心，通过电话和电子邮件回答问题，并通过网站、名单服务器、时事通讯和每年约1,000人参加的社区活动传播信息。CEHS计划每年由该科学领域的专家组成的外部咨询委员会、具有UCD管理经验的著名科学家组成的内部咨询委员会和CEHS教职员工组成的执行委员会进行审查。UCD做出了强有力的支持承诺(约40%/年)，为所有中心调查人员提供工资和福利，为CEHS提供场地和购买设备。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: The major goal of the NIEHS Center for Environmental Health Sciences at UCD is to maintain a strong program in the toxicology of agrochemicals and related xenobiotics, particularly relating to human health and the mechanistic aspects of toxicology. A team of 20 Center investigators whose interests are specifically aligned with Center goals has been assembled. Collectively these investigators are in charge of almost $12 million per year (direct costs) in research grants. The Center members include new and experienced scientists, many fields of interest, and strong histories of collaboration. To build an infrastructure which facilitates relationships within and between groups, the Center has been reorganized to form seven facility/service cores: (1) Administrative, (2) Analytical Biochemistry, (3) Cell/Tissue Culture, (4) Cellular and Molecular Imaging, (5) Field Studies (6) Functional Genomics and Molecular Biology, and (7) Primate/Animal Models. In addition, to promote focused research efforts, intellectual stimulation and synergistic interactions, five research cores have been formed: (1) Epidemiology, (2) Molecular Neurotoxicology, (3) Reproductive and Developmental Toxicology, (4) Respiratory Toxicology, and our newest core, (5) Toxicogenomics. The composition of these cores changed to provide flexibility to the Center's research directions. The Pilot Projects Program is used to bring in new investigators and research ideas. An Affiliate Scientist category was developed to recognize interactions with UCD faculty through a less formal mechanism than full membership, and 11 new Affiliate members were appointed. The new COEP has been carefully guided by the Center Director, and under the leadership of the new coordinator, Rebecca Morrison, the COEP Mini-Grants Program has been an effective program to identify new ideas. From those ideas came a successful long-term program that currently supports four outreach programs for agricultural workers, three K-12 programs, and an alumni/corporate outreach program. In addition, during the current project period, the COEP conducted a national symposium on aging and a town-hall meeting, and sponsored the International Congress on Ecosystem Health in 1999 and the Dioxin 2000 Twentieth International Symposium on Halogenated Environmental Organic Pollutants and POPS. The COEP also serves as an Environmental Health Information Center for the public, answering questions via phone and e-mail, and disseminating information via websites, list servers, newsletters, and annual community events attended by approximately 1,000 people/year. The CEHS program is reviewed annually by the External Advisory Committee consisting of experts in this area of science, the Internal Advisory Committee consisting of eminent scientists with administrative experience at UCD, and the Executive Committee composed of CEHS faculty. The UCD has made a strong commitment of support (approximately 40%/year) by providing salaries and benefits for all Center investigators, providing space, and purchasing equipment for the CEHS.