EFFECT OF INCREASING T ON INSULN SENSITIVITY IN MEN WITH METABOLIC SYNDROME

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 一些证据一致地指出男性睾酮和胰岛素之间存在反比关系，但目前关于因果关系的数据相互矛盾。 一方面，睾酮管理已被证明可以改善肥胖男性的胰岛素抵抗。 另一方面，减肥已被证明可以增加睾丸激素水平。因此，需要建立这些关系的精确定义并定义其因果决定因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Several lines of evidence consistently point to an inverse relationship between testosterone and insulin in men, but current data on causality are conflicting. On the one hand, testosterone administration has been shown to ameliorate insulin resistance in obese men. On the other hand, weight loss has been demonstrated to increase testosterone levels. Thus, precise definitions of these relationships need to be established and their causative determinants defined.