STRUCTURAL STUDIES OF NUCLEIC ACIDS INVOLVED IN HOMOLOGOUS RECOMBINATION: HIV

参与同源重组的核酸的结构研究:HIV

基本信息

  • 批准号:
    7181909
  • 负责人:
  • 金额:
    $ 2.54万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2005
  • 资助国家:
    美国
  • 起止时间:
    2005-08-01 至 2006-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): We will continue to operate BioCARS, a nationally-available research resource for synchrotron-based macromolecular crystallography at the Advanced Photon Source, Argonne National Laboratory. The facility contains three experimental stations, one served by either an undulator or a wiggler insertion device source and two served by a bending magnet source, all of which can be used simultaneously. All stations and the associated control areas are embedded in a BL3-level biosafety facility, to permit the safe study of, for example, pathogenic human viruses. Research by users has successfully and productively concentrated on de novo structure determination by MAD phasing; on the collection of accurate, high resolution, monochromatic data; on the study of crystals with large unit cell dimensions; and on time-resolved crystallography on time scales down to a few nanoseconds. We will continue to emphasize these areas and to support the most challenging user experiments, through our experienced technical and scientific staff. In a facility that is unique nationally and one of three internationally, we will further develop time-resolved crystallography in both core and collaborative research, largely on the insertion device station. Advances in this scientific technique have led to much broader user interest in applying it to a wide variety of systems, since it offers new insights into biological mechanism and function. Upgrades will be made to the X-ray beam lines, both to replace those older components damaged by radiation and by heating and to afford smaller focal spots that are better matched to the smaller crystals that users wish to examine. Detector and data acquisition and control software will be improved, both to support collaborative projects in structural genomics that demand high data throughput, and to enable telecrystallography, in which the user can participate effectively in all aspects of the synchrotron experiment but need not be physically present at BioCARS. Strategies for improving the diffraction quality of crystals at both room and cryogenic temperatures by annealing will be implemented. In all cases, these developments are aimed at enhancing the throughput of excellent, high-resolution diffraction data and solved scientific problems, by satisfied users.
描述(由申请人提供):我们将继续运行BioCARS,这是一个国家可用的同步加速器大分子晶体学研究资源,位于阿贡国家实验室的先进光子源。该设施包含三个实验站,其中一个由波动器或摆动插入装置源提供服务,另两个由弯曲磁铁源提供服务,所有这些都可以同时使用。所有监测站和相关控制区均置于bl3级生物安全设施中,以便对诸如致病性人类病毒等进行安全研究。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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FRANCES J HAYES其他文献

FRANCES J HAYES的其他文献

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{{ truncateString('FRANCES J HAYES', 18)}}的其他基金

EFFECT OF INCREASING T ON INSULN SENSITIVITY IN MEN WITH METABOLIC SYNDROME
增加 T 对代谢综合征男性胰岛素敏感性的影响
  • 批准号:
    7731258
  • 财政年份:
    2008
  • 资助金额:
    $ 2.54万
  • 项目类别:
Modulation of Insulin Action by Testosterone in Men
睾酮对男性胰岛素作用的调节
  • 批准号:
    7146740
  • 财政年份:
    2006
  • 资助金额:
    $ 2.54万
  • 项目类别:
Modulation of Insulin Action by Testosterone in Men
睾酮对男性胰岛素作用的调节
  • 批准号:
    7254704
  • 财政年份:
    2006
  • 资助金额:
    $ 2.54万
  • 项目类别:
EFFECT OF INCREASING T ON INSULN SENSITIVITY IN MEN WITH METABOLIC SYNDROME
增加 T 对代谢综合征男性胰岛素敏感性的影响
  • 批准号:
    7607068
  • 财政年份:
    2006
  • 资助金额:
    $ 2.54万
  • 项目类别:
INTERPLAY BETWEEN GONADAL STEROIDS AND INSULIN IN MEN
男性性腺类固醇和胰岛素之间的相互作用
  • 批准号:
    6845335
  • 财政年份:
    2004
  • 资助金额:
    $ 2.54万
  • 项目类别:
INTERPLAY BETWEEN GONADAL STEROIDS AND INSULIN IN MEN
男性性腺类固醇和胰岛素之间的相互作用
  • 批准号:
    6720874
  • 财政年份:
    2004
  • 资助金额:
    $ 2.54万
  • 项目类别:
INTERPLAY BETWEEN GONADAL STEROIDS AND INSULIN SENSITIVITY IN MEN
男性性腺类固醇与胰岛素敏感性之间的相互作用
  • 批准号:
    7205043
  • 财政年份:
    2004
  • 资助金额:
    $ 2.54万
  • 项目类别:
STRUCTURAL STUDIES OF NUCLEIC ACIDS
核酸的结构研究
  • 批准号:
    6978176
  • 财政年份:
    2004
  • 资助金额:
    $ 2.54万
  • 项目类别:
INTERPLAY BETWEEN GONADAL STEROIDS AND INSULIN SENSITIVITY IN MEN
男性性腺类固醇与胰岛素敏感性之间的相互作用
  • 批准号:
    6982561
  • 财政年份:
    2003
  • 资助金额:
    $ 2.54万
  • 项目类别:
INTERPLAY BETWEEN GONADAL STEROIDS AND INSULIN IN MEN
男性性腺类固醇和胰岛素之间的相互作用
  • 批准号:
    6516784
  • 财政年份:
    2000
  • 资助金额:
    $ 2.54万
  • 项目类别:

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