GROWTH HORMONE SUPPRESSION IN HEALTHY CHILDREN FOLLLOWING ASMINISTRATION OF AN

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 这项研究的目的是确定在喝葡萄糖（一种糖）后的两小时内，生长激素（脑垂体产生的一种化学物质）的水平下降了多少。 这个测试是用来确定一个人是否制造过多的生长激素。 通过研究青春期每个阶段的儿童，我们希望为儿童的这种测试设定标准水平，并帮助我们更好地诊断脑垂体分泌过多激素的情况。 具体目标1：我们将在不同青春期（坦纳）阶段的健康男孩和女孩中确定口服葡萄糖后GH抑制的最低点。 具体目标2：我们还将确定青春期阶段是否影响GH的最低值。 具体目标3：我们将研究GH水平和GH抑制的程度与口服葡萄糖后的脂肪量，瘦体重和骨密度之间的关系，在女孩和男孩年龄12至17岁，在腰椎和髋关节。 特定目标将仅限于12-17岁的儿童，因为仅在该年龄组中进行身体成分和骨密度的DXA扫描。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine how much level of growth hormone ( a chemical made by the pituitary gland in the brain) comes down over a two-hour period after a drink of glucose (a kind of sugar). This test is used to determine if a person is making too much growth hormone. By studying children at each stage of puberty, we hope to set standard levels for this test in children and help us better diagnose conditions where the pituitary gland is making too much hormone. Specific Aim 1: We will determine nadir of GH suppression following oral glucose administration in healthy boys and girls in different pubertal (Tanner) stages. Specific Aim 2: We will also determine whether pubertal stage affects the nadir of GH. Specific Aim 3: We will examine the relationship between GH levels and the extent of GH suppression following oral glucose with fat mass, lean mass and bone density, in girls and boys ages 12 through 17 years, at the lumbar spine and hip. The Specific Aim will be limited to children 12-17 years old, because DXA scan for body composition and bone density will be performed only in this age group.