GROWTH HORMONE SUPPRESSION IN HEALTHY CHILDREN FOLLLOWING ASMINISTRATION OF AN

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这项研究的目的是确定饮用葡萄糖（一种糖）后两小时内生长激素（一种由大脑垂体产生的化学物质）水平下降了多少。 该测试用于确定一个人是否产生过多的生长激素。 通过研究青春期每个阶段的儿童，我们希望为儿童的这项测试设定标准水平，并帮助我们更好地诊断脑下垂体产生过多激素的情况。 具体目标 1：我们将确定不同青春期 (Tanner) 阶段的健康男孩和女孩口服葡萄糖后 GH 抑制的最低点。 具体目标 2：我们还将确定青春期是否影响 GH 最低点。 具体目标 3：我们将研究 12 至 17 岁女孩和男孩腰椎和髋部的 GH 水平和口服葡萄糖后 GH 抑制程度与脂肪量、去脂量和骨密度之间的关系。 具体目标将仅限于 12-17 岁的儿童，因为仅在该年龄段进行身体成分和骨密度的 DXA 扫描。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine how much level of growth hormone ( a chemical made by the pituitary gland in the brain) comes down over a two-hour period after a drink of glucose (a kind of sugar). This test is used to determine if a person is making too much growth hormone. By studying children at each stage of puberty, we hope to set standard levels for this test in children and help us better diagnose conditions where the pituitary gland is making too much hormone. Specific Aim 1: We will determine nadir of GH suppression following oral glucose administration in healthy boys and girls in different pubertal (Tanner) stages. Specific Aim 2: We will also determine whether pubertal stage affects the nadir of GH. Specific Aim 3: We will examine the relationship between GH levels and the extent of GH suppression following oral glucose with fat mass, lean mass and bone density, in girls and boys ages 12 through 17 years, at the lumbar spine and hip. The Specific Aim will be limited to children 12-17 years old, because DXA scan for body composition and bone density will be performed only in this age group.