GROWTH HORMONE SUPPRESSION IN HEALTHY CHILDREN FOLLLOWING ASMINISTRATION OF AN

健康儿童服用抗生素后生长激素受到抑制

• 批准号: 7731319
• 负责人: Madhusmita Misra
• 金额: $ 0.02万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7731319
• 关键词: 17 year old; Affect; Age; Body Composition; Bone Density; Brain; Chemicals; Child; Computer Retrieval of Information on Scientific Projects Database; Condition; Diagnosis; Dual-Energy X-Ray Absorptiometry; Fatty acid glycerol esters; Funding; Glucose; Grant; Hip region structure; Hormones; Hour; Institution; Oral; Persons; Pituitary Gland; Puberty; Purpose; Research; Research Personnel; Resources; Scanning; Somatotropin; Source; Staging; Standards of Weights and Measures; Testing; United States National Institutes of Health; Vertebral column; age group; boys; drinking; girls; sugar

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine how much level of growth hormone ( a chemical made by the pituitary gland in the brain) comes down over a two-hour period after a drink of glucose (a kind of sugar). This test is used to determine if a person is making too much growth hormone. By studying children at each stage of puberty, we hope to set standard levels for this test in children and help us better diagnose conditions where the pituitary gland is making too much hormone. Specific Aim 1: We will determine nadir of GH suppression following oral glucose administration in healthy boys and girls in different pubertal (Tanner) stages. Specific Aim 2: We will also determine whether pubertal stage affects the nadir of GH. Specific Aim 3: We will examine the relationship between GH levels and the extent of GH suppression following oral glucose with fat mass, lean mass and bone density, in girls and boys ages 12 through 17 years, at the lumbar spine and hip. The Specific Aim will be limited to children 12-17 years old, because DXA scan for body composition and bone density will be performed only in this age group.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是确定在饮用葡萄糖(一种糖)后的两个小时内，生长激素(一种由大脑中的脑下垂体产生的化学物质)的水平下降了多少。这项测试是用来确定一个人是否分泌了太多的生长激素。通过研究青春期每个阶段的儿童，我们希望为儿童的这项测试设定标准水平，并帮助我们更好地诊断脑下垂体分泌过多激素的情况。 具体目标1：我们将确定口服葡萄糖后不同青春期(Tanner)健康男孩和女孩GH抑制的最低点。 具体目标2：我们还将确定青春期阶段是否影响生长激素的最低点。 具体目标3：我们将研究12至17岁的女孩和男孩腰椎和髋部的生长激素水平和口服葡萄糖后生长激素抑制程度与脂肪质量、瘦质量和骨密度的关系。具体目标将限于12-17岁的儿童，因为身体成分和骨密度的DXA扫描将仅在这个年龄段进行。