GENETICS OF BRAIN STRUCTURE AND FUNCTION
GENETICS OF BRAIN STRUCTURE AND FUNCTION
批准号:
7718755
负责人:
DAVID B GLAHN
金额:
$0.77万
依托单位国家:
美国
项目类别:
财政年份:
2008
资助国家:
美国
项目状态:
已结题
起止时间:
2008-04-01 至 2008-05-31
关键词:
ArchitectureBase of the BrainBiocompatible MaterialsBioinformaticsBiologicalBiologyBiomedical ResearchBrainBrain DiseasesCandidate Disease GeneCommunitiesComputer Retrieval of Information on Scientific Projects DatabaseComputer SimulationDataData CorrelationsDiseaseDissectionExtended FamilyFoundationsFoxesFundingGene ExpressionGenesGeneticGenetic ResearchGenomeGenome ScanGenotypeGoalsGrantHealth SciencesHeritabilityHuman GeneticsIndividualInstitutionInterventionLeukocytesLocalizedMagnetic Resonance ImagingMeasuresMental disordersMethodsMexican AmericansNational Institute of Mental HealthNeurocognitiveParticipantPhenotypePositioning AttributePsyche structurePublic HealthQualifyingQuantitative GeneticsQuantitative Trait LociResearchResearch PersonnelResourcesSamplingSourceStructureSusceptibility GeneTexasUnited States National Institutes of HealthUniversitiesVariantbaseclinically relevantendophenotypegene discoverygenetic analysisgenetic pedigreeimprovedindexingmemberneuroimagingneuropsychologicalnovelresearch studytranscriptomics
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
2007
OBJECTIVE: The goal of this project is to identify quantitative trait loci associated with variation in brain structure and function. The ultimate promise of this research is the discovery of genes that predispose to brain disorders and mental illnesses. We believe that the analysis of genetic influences on brain structure and function in randomly sampled extended pedigrees will provide significant clues regarding the genes that are involved in both normal and pathological brain function. The focus of the project is on the genetic dissection of quantitative endophenotypes that more directly index the underlying biological basis of brain function than do discrete disease states themselves.
RESRARCH PLAN AND METHODS: We will perform neuroimaging and conduct neuropsychological examinations on Mexican American individuals who have been part of our ongoing genetic research studies for the past 15 years. All participants were previously genotyped and our plan is to utilize existing genome scan and genome-wide quantitative transcriptomic data for correlation with neuroanatomic and neurocognitive variables. Our specific aims are to: 1) perform high quality brain magnetic resonance imaging and neuropsychological examinations on 1,000 Mexican Americans who are members of approximately 30 large extended families, 2) assess the quantitative genetic architecture of brain-related phenotypes by estimating their heritabilities and their genetic correlations, 3) classify specific brain morphological variables and quantitative leukocyte-derived gene expression measures as endophenotypes related to brain function, 4) localize QTLs influencing variation in the quantitative brain-related phenotypes by performing linkage-based genome scanning using the variance component method, 5) refine the position of localized QTLs and identify positional candidate loci using an objective prioritization strategy that jointly utilizes in silico bioinformatics, genetic, and transcriptional data, and 6) identify the most likely functional variations within the two best positional candidate genes. This project involves coordinated R01 applications from Dr. John Blangero, Southwest Foundation for Biomedical Research, and Drs. David Glahn and Peter Fox, University of Texas Health Science Center at San Antonio. Our data and biomaterials will be incorporated into the NIMH Human Genetics Initiative making them available to qualified researchers in the wider scientific community.
CLINICAL RELEVANCE: Brain-related mental diseases are a major public health burden whose biology is still largely unknown. By identifying genes involved in brain function and structure, we will provide novel biological candidates for the determinants of such diseases and thus improve potential for intervention.
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NEUROPSYCHOLOGICAL AND NEUROIMAGING ABNORMALITIES IN SIBLING PAIRS DISCORDANT
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批准号:7718751
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项目类别:
-
资助金额:$0.02万
-
财政年份:2008
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负责人:DAVID B GLAHN
-
依托单位:
EXAMINING THE NEURAL SUBSTRATES OF DECLARATIVE MEMORY DEFICITS IN BIPOLAR DIS
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批准号:7627563
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项目类别:
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资助金额:$0.17万
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财政年份:2007
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负责人:DAVID B GLAHN
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依托单位:
GENETICS OF BRAIN STRUCTURE AND FUNCTION
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批准号:7627569
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项目类别:
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资助金额:$3.12万
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财政年份:2007
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负责人:DAVID B GLAHN
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依托单位:
NEUROPSYCHOLOGICAL AND NEUROIMAGING ABNORMALITIES IN SIBLING PAIRS DISCORDANT
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批准号:7627568
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项目类别:
-
资助金额:$0.33万
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财政年份:2007
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负责人:DAVID B GLAHN
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依托单位:
EXAMINING THE NEURAL SUBSTRATES OF DECLARATIVE MEMORY DEFICITS IN BIPOLAR DIS
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批准号:7378224
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项目类别:
-
资助金额:$0.62万
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财政年份:2006
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负责人:DAVID B GLAHN
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依托单位:
NEUROPSYCHOLOGICAL AND NEUROIMAGING ABNORMALITIES IN SIBLING PAIRS DISCORDANT
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批准号:7378229
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项目类别:
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资助金额:$0.4万
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财政年份:2006
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负责人:DAVID B GLAHN
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依托单位:
IMAGING THE EFFECTS OF EXOGENOUS CORTISOL IN THE HUMAN BRAIN
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批准号:7378203
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项目类别:
-
资助金额:$0.27万
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财政年份:2006
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负责人:DAVID B GLAHN
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依托单位:
EXAMINING THE NEURAL SUBSTRATES OF DECLARATIVE MEMORY DEFICITS IN BIPOLAR DIS
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批准号:7204823
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项目类别:
-
资助金额:$0.72万
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财政年份:2005
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负责人:DAVID B GLAHN
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依托单位:
IMAGING THE EFFECTS OF EXOGENOUS CORTISOL IN THE HUMAN BRAIN
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批准号:7204808
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项目类别:
-
资助金额:$0.62万
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财政年份:2005
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负责人:DAVID B GLAHN
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依托单位:
DISSOCIATING CONTEXTUAL PROCESSING DEFICITS IN SCHIZOPHRENIA
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批准号:7204816
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项目类别:
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资助金额:$0.19万
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财政年份:2005
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负责人:DAVID B GLAHN
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依托单位:
ASSESSING NEUROPHYSIOLOGIC CORRELATES OF CONTEXTUAL PROCESSING DEFECTS IN SCHIZO
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批准号:7204825
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项目类别:
-
资助金额:$0.67万
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财政年份:2005
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负责人:DAVID B GLAHN
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依托单位:
Contextual Processing Deficits in Schizophrenia
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批准号:6972412
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项目类别:
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资助金额:$0.72万
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财政年份:2004
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负责人:DAVID B GLAHN
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依托单位: