CLINICAL TRIAL: TMS FOR THE TREATMENT OF SEVERELY AFFECTED STROKE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这是一项II期研究，旨在前瞻性地研究一种治疗严重运动障碍的中风患者的新疗法。这项研究的理由是，运动缺陷是影响他们生活质量的一个重要因素，rTMS已被证明与中风患者的运动改善有关。这项治疗试验将是一项为期10天的随机、平行组设计、双盲、不完全交叉、安慰剂对照的临床试验。这项研究的主要目的是确定在有严重运动缺陷的中风患者中使用rTMS是否可以改善运动功能。患者将根据扩散张量成像的结果进行选择。因此，这项研究的第二个目的是调查扩散张量成像(DTI)是否可以作为中风患者rTMS治疗良好反应的新标记物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a phase II study that aims to investigate prospectively a new therapy for stroke patients with severe motor deficits. The justification of this study is that the motor deficits are an important factor for their quality of lives and rTMS has been shown to be associated with motor improvement in patients with stroke. This therapeutic trial will be a 10-day, randomized, parallel-group design, double-blind, incomplete cross-over, placebo controlled clinical trial. The primary aim of this investigation is to determine whether the use of rTMS in patients with stroke and severe motor deficits improves motor function. Patients will be selected based on the results of diffusion tensor imaging. Therefore, the second aim of this study is to investigate whether diffusion tensor imaging (DTI) could be a novel marker for good response to rTMS therapy in stroke patients.