EFFECT OF LETROZOLE ON BONE MARKERS AND BLOOD PRESSURE

来曲唑对骨标志物和血压的影响

• 批准号: 7719118
• 负责人: Faryal Sardar Mirza
• 金额: $ 0.06万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719118
• 关键词: Ambulatory Blood Pressure Monitoring; Androgens; Aromatase; Aromatase Inhibitors; Blood Pressure; Bone Resorption; Class; Computer Retrieval of Information on Scientific Projects Database; Consultations; Cytochrome P450; Disease-Free Survival; Enzymes; Estradiol; Estrogens; Funding; Gonadal Steroid Hormones; Grant; Institution; Label; Letrozole; Neurocognitive; Oncologist; Osteogenesis; Patients; Peripheral; Pilot Projects; Plasma; Postmenopause; Research; Research Personnel; Resources; Source; Staging; Tamoxifen; Tissues; United States National Institutes of Health; Week; Woman; bone; improved; malignant breast neoplasm

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Studies using aromatase inhibitors (AI) have recently demonstrated improved disease free survival after five years of tamoxifen therapy for early stage breast cancer in postmenopausal women. AI are a class of compounds that inhibit the synthesis of estrogens from androgens by blocking aromatase, a cytochrome P450 enzyme, which catalyzes the peripheral conversion of androgens to estrogens, thereby reducing the tissue and plasma concentration of estradiol to below castrate levels. We hypothesize that with suppression of estradiol, letrozole, the most potent aromatase inhibitor, will cause a significant increase in markers of bone resorption and bone formation, along with an increase in baseline blood pressure and loss of nocturnal dipping of blood pressure. The following specific aims will be studied: To determine the effects of letrozole on sex hormone levels and the relationship of change in sex hormone levels to the change in bone markers. To determine the change in markers of bone resorption and formation. To examine the effects of letrozole on 24 hr ambulatory blood pressure monitoring and office blood pressure. To determine change in parameters of neurocognitive function with letrozole therapy. This will be a 12 week, open label pilot study evaluating women with primary breast cancer, who have completed five years of tamoxifen treatment and are opting to choose letrozole as treatment in consultation with their oncologist. The patients will serve as their own controls.

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